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Home / Proteins & Peptide

EGF, Rat

SKU : BHP18500241

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Mfr.No.	IX03066, IX03066-1, IX03066-100, IX03066-20
Description	Epidermal Growth Factor (EGF) is a cytokine with 53 amino acids, originally found in mouse submaxillary gland. EGF binds to EGF receptors, ErbB1 and B4, and causes them to be dimerized and phosphorylated. The dimerized and phosphorylated EGFR can bind to several intracellular targets, such as phospholipase Cgamma and Ras-GTPase-acting protein, and achieve a series of cascade reactions. EGF is involved in the regulation of cell proliferation and differentiation, and is up-regulated during wound healing, accelerating reepitheliazation and increasing tensile strength. It also stimulates neurite outgrowth and increases the uptake of dopamine in the central nervous system. On the other hand, EGF is up-regulated in the glioma cancer, and related to the length of survivals of the patients.Recombinant rat Epidermal Growth Factor (rrEGF) produced in E. coli is a single non-glycosylated polypeptide chain containing 54 amino acids. A fully biologically active molecule, rrEGF has a molecular mass of 6.3 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques.
Reconstitution	Reconstituted in ddH2O at 100 ug/mL.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	6.3 kDa, observed by reducing SDS-PAGE.
Source	E. coli
Host	Rat
Accession Number	P07522
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED50 0.08 ng/mL, measured by a cell proliferation assay using 3T3 cells, corresponding to a specific activity of 1.25x 107 units/mg.

Synonyms	Epidermal Growth Factor, Urogastrone, URG
Sequence	MNSNTGCPPS YDGYCLNGGV CMYVESVDRY VCNCVIGYIGERCQHRDLRW WKLR

Purity	95% by SDS-PAGE analysis.
Storage	Lyophilized recombinant rat Epidermal Growth Factor (rrEGF) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rrEGF should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500241-1	IX03066-1	1mg	$500		Add to Cart
BHP18500241-2	IX03066-100	100ug	$95		Add to Cart
BHP18500241-3	IX03066-20	20ug	$32		Add to Cart

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