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Home / Proteins & Peptide

EGF R/ErbB1 Fc Chimera, Human

SKU : BHP18500499

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iXCells Biotechnologies

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Mfr.No.	IX03381, IX03381-1, IX03381-10, IX03381-50
Description	EGF Receptor, also known as ERBB, ERBB1 and HER1, is a type I transmembrane protein belonging to the tyrosine protein kinase family. It binds to a subset of EGF family ligands, including EGF, TGF-alpha, amphiregulin, EPGN, BTC, EREG and HBEGF. Ligand binding triggers receptor homo- or hetero-dimerization, which induces downstream kinase activation, tyrosine phosphorylation and cell signaling. EGF receptor signaling has been shown to regulate cell proliferation, differentiation, motility and apoptosis.?Recombinant Human EGF-R/ErbB1 Fc Chimera produced in CHO cells is a polypeptide chain containing 854 amino acids with the C-termimal human IgG1 Fc fragment. A fully biologically active molecule, rhEGF-R/ErbB1 has a molecular mass of 12-125 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized from a 0.2 um filtered solution in PBS.
Molecular Weight	120-125 kDa, observed by reducing SDS-PAGE.
Source	CHO
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Bioactivity	Measured by its ability to bind rhEGF in a functional ELISA with an estimated KD 10 nM.

Sequence	LEEKKVCQ GTSNKLTQ LGTFEDHF LSLQRMFN NCEVVLGN?LEITYVQR NYDLSFLK TIQEVAGY VLIALNTV ERIPLENL?QIIRGNMY YENSYALA VLSNYDAN KTGLKELP MRNLQEIL?HGAVRFSN NPALCNVE SIQWRDIV SSDFLSNM SMDFQNHL?GSCQKCDP SCPNGSCW GAGEENCQ KLTKIICA QQCSGRCR?GKSPSDCC HNQCAAGC TGPRESDC LVCRKFRD EATCKDTC?PPLMLYNP TTYQMDVN PEGKYSFG ATCVKKCP RNYVVTDH?GSCVRACG ADSYEMEE DGVRKCKK CEGPCRKV CNGIGIGE?FKDSLSIN ATNIKHFK NCTSISGD LHILPVAF RGDSFTHT?PPLDPQEL DILKTVKE ITGFLLIQ AWPENRTD LHAFENLE?IIRGRTKQ HGQFSLAV VSLNITSL GLRSLKEI SDGDVIIS?GNKNLCYA NTINWKKL FGTSGQKT KIISNRGE NSCKATGQ?VCHALCSP EGCWGPEP RDCVSCRN VSRGRECV DKCNLLEG?EPREFVEN SECIQCHP ECLPQAMN ITCTGRGP DNCIQCAH?YIDGPHCV KTCPAGVM GENNTLVW KYADAGHV CHLCHPNC?TYGCTGPG LEGCPTNG PKIPS

Purity	95% as analyzed by reducing SDS-PAGE.
Storage	Lyophilized recombinant Human EGF-R/ErbB1 Fc Chimera remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human EGF-R/ErbB1 should be stable up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500499-1	IX03381-1	1mg	$874		Add to Cart
BHP18500499-2	IX03381-10	10ug	$50		Add to Cart
BHP18500499-3	IX03381-50	50ug	$113		Add to Cart

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