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Home / Proteins & Peptide

Cono VGRPRF-amide

SKU : BHP21300153

A Specific Potentiator of ASIC3 Channel

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Mfr.No.	STC-172, STC-172_0.5 mg, STC-172_1 mg, STC-172_10 mg, STC-172_5 mg
Description	A Specific Potentiator of ASIC3 Channel
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C33H55N13O6.
Background	Cono VGRPRF-amide conotoxin is a peptide toxin originally isolated from the venom of the cone snail Conus textile and strongly potentiates ASIC3 by slowing the desensitization kinetics of the channel. Cono VGRPRF-amide belongs to the subgroup of cono-RFamides containing C-terminal sequence of four amino acids and a C-terminal Arg-Phe-NH2 (RFa) motif1.ASIC channels are proton-gated Na+ channels directly activated by extracellular protons. They are expressed throughout the CNS and the peripheral nervous systeM They are responsible for synaptic transmission and detection of painful acidosis. ASICs play an important role in several physiological and pathological conditions including synaptic plasticity and learning, fear conditioning, and neurodegeneration associated with ischemic stroke1,2.
Biological Activity	Cono VGRPRF-amide is an ASIC3 channel positive modulator1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	730 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Concentration	50 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Phe6-C-terminal amidation
Origin	Conus textile

Gene Id	ASIC3
Sequence	VGRPRF-NH2
Target	ASIC3 channel

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Reimers, C. et al. (2017) Proc. Natl. Acad. Sci. U. S. A. 114, E3507. Osmakov, D.I. et al. (2017) Front. Mol. Neurosci. 10, 282. Reimers, C. et al. (2017) Proc. Natl. Acad. Sci. U. S. A. 114, E3507.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300153-1	STC-172_0.5 mg	0.5 mg	$117		Add to Cart
BHP21300153-2	STC-172_1 mg	1 mg	$168		Add to Cart
BHP21300153-3	STC-172_10 mg	10 mg	$926		Add to Cart
BHP21300153-4	STC-172_5 mg	5 mg	$595		Add to Cart

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