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Home / Proteins & Peptide

Conantokin G

SKU : BHP21300183

A Selective and Competitive Antagonist of GluN2B Receptor

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Mfr.No.	STC-666, STC-666_0.5 mg, STC-666_1 mg, STC-666_10 mg, STC-666_2.5 mg, STC-666_5 mg
Description	A Selective and Competitive Antagonist of GluN2B Receptor
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C88H138N26O44
Background	Conantokin G is a 17 amino acid peptide toxin originally isolated from Conus geographus venoM The toxin acts as a selective antagonist of the GluN2B, a subunit of NMDA receptors1-3. Conantokin G structure includes gamma-carboxiglutamic acid which coordinates binding of 4 calcium ions1,2.Conantokin G has IC50 values of 0.48 uM in hippocampal and cortical neurons, and 0.1 uM in Xenopus oocytes expressing the GluN1-GluN2B subunits1. In vitro studies of neuronal cultures have revealed anti-apoptotic properties of Conantokin G. In animal models, Conantokin G has been successfully tested as an anti-convulsant and as an anti-analgesic agent.NMDA receptors belong to the family of ionotropic receptors coactivated by glutamate and glycine. They play a central role in neuronal plasticity, learning, and memory3.
Biological Activity	ConantokinG is a GluN2B competitive antagonist1.
Formulation	Lyophilized from double distilled water (ddH2O).
Molecular Weight	2264.2 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P07231
Concentration	500 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	93438-65-4
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	X = 4-Carboxyglutamate, Asp17 - C-terminal amidation
Origin	Conus geographus (Geography cone) (Nubecula geographus)

Synonyms	Con-G, CGX-1007, Conotoxin GV, Sleeper peptide
Gene Id	GRIN2B
Sequence	GEXXLQXNQXLIRXKSN-NH2
Target	GluN2B receptor

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Reyes-Guzman, E.A. et al. (2017) BMC Neurosci. 18, 44. Balsara, R. et al. (2015) PLoS One 10, e0122840. Balsara, R. et al. (2012) Neuropharmacology 62, 2227. Balsara, R. et al. (2012) Neuropharmacology 62, 2227.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300183-1	STC-666_0.5 mg	0.5 mg	$110		Add to Cart
BHP21300183-2	STC-666_1 mg	1 mg	$218		Add to Cart
BHP21300183-3	STC-666_10 mg	10 mg	$1248		Add to Cart
BHP21300183-4	STC-666_2.5 mg	2.5 mg	$490		Add to Cart
BHP21300183-5	STC-666_5 mg	5 mg	$780		Add to Cart

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