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Home / Proteins & Peptide

Bombesin

SKU : BHP21300050

A Ligand of the Bombesin G-Protein Coupled Receptor

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Mfr.No.	GPB-100, GPB-100_0.5 mg, GPB-100_1 mg, GPB-100_10 mg, GPB-100_25 mg, GPB-100_5 mg
Description	A Ligand of the Bombesin G-Protein Coupled Receptor
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C71H109N23O19S
Background	Bombesin is an active neuropeptide originally isolated from amphibian skin but also found in the central and peripheral nervous systems of amphibians1. Later it was established that mammals and birds express two family groups of endogenous Bombesin-like factors, the gastrin-releasing peptides and neuromedin B2. The biological activities of bombesin are mediated through a family of three specific G-protein coupled receptors (GPCRs): BB1 which is also known as a neuromedin B receptor, BB2 also known as a gastrin-releasing peptide receptor and BB3 which is a low affinity binder for the Bombesin-like factors3,4.Bombesin and Bombesin-like factors show a broad range of biological activities such as regulation of smooth muscle contraction, stimulation of neuropeptide and hormone secretion, modulation of neural activity, growth regulation, and mediate anorexic effects in the hypothalamus5.
Biological Activity	Bombesin is a GPCR external ligand that mediates the inhibition of food intake and regulates the stress and fear response1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	1620.8 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Concentration	1 - 100 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: No
Cas Number	31362-50-2
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Glu1 - Pyrrolidone carboxylic acid
Origin	Bombina bombina (Fire-bellied toad)

Gene Id	GRPR, NMBR, BRS3
Sequence	EQRLGNQWAVGHLM-OH
Target	Bombesin receptors

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Calcium imaging assay

Reference	Battey, J. and Wada, E. (1991) Trends Neurosci. 14, 524. Ohki-Hamazaki, H. et al. (2005) Int. J. Dev. Biol. 49, 293. Wada E. et al. (1991) Neuron 6, 421. Moody, T. W. and Merali, Z. (2004) Peptides 25, 511. Anastasi, A. (1971) Naunyn. Schmiedebergs. Arch. Pharmakol. 269, 135. Casanueva, F.F. et al. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 1406.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300050-1	GPB-100_0.5 mg	0.5 mg	$55		Add to Cart
BHP21300050-2	GPB-100_1 mg	1 mg	$75		Add to Cart
BHP21300050-3	GPB-100_10 mg	10 mg	$354		Add to Cart
BHP21300050-4	GPB-100_25 mg	25 mg	$703		Add to Cart
BHP21300050-5	GPB-100_5 mg	5 mg	$243		Add to Cart

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