Biotinylated SARS-CoV-2 S Protein RBD-SD1 is produced by our Mammalian expression system and the target gene encoding Arg319-Ser591 is expressed with a Avi, 6His tag at the C-terminus.
Alternative Names
2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein
Background
The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
Biological Activity
Freeze-thaw stability is tested by repeated freeze-thaw cycles. The result showed that product bioactivity is no significant differences after freeze-thawing 14 times.
Molecular Weight
33.2kDa
Accession Number
QHD43416.1
Shipping
The product is shipped on dry ice pack.Upon receipt, store it immediately at the temperature listed below.
Purity
Greater than 95%
Storage
Reconstituted protein solution should be stored at <= -20°C.
Reviews of Biotinylated 2019-nCoV S Protein RBD-SD1 (C-Avi-6His)