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Home / Proteins & Peptide

beta-Pompilidotoxin

SKU : BHP21300092

An Enhancer of NaV Currents

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Mfr.No.	P-180, P-180_1 mg, P-180_10 mg, P-180_25 mg, P-180_5 mg
Description	An Enhancer of NaV Currents
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C71H124N22O17
Background	beta-PMTX was originally isolated from Anoplius samariensis and Batozonellus maclifrons wasps. This is a synthetic version of the peptide.beta-PMTX is a homologous peptide to alpha-PMTX (position 12 is Arginine instead of Lysine). beta-PMTX induces repetitive action potentials and facilitates both excitatory and inhibitory synaptic transmission.Recently it was found that this toxin slows the Na+-channel inactivation, without changing the peak current-voltage relationship or the activation time course of the TTX-sensitive Na+ currents in the neuromuscular synapse of the lobster walking leg and in the rat trigeminal ganglion neurons.1-3 beta-PMTX is five times more potent than alpha-PMTX.1,2
Biological Activity	beta-Pompilidotoxin slows NaV channel inactivation, without changing the peak current-voltage relationship or the activation time course of the TTX-sensitive Na+ currents in the neuromuscular synapse1-3. beta-Pompilidotoxin is five times more potent than alpha-Pompilidotoxin1,2.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	1558 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P69392
Concentration	10 - 100 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	216064-36-7
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Lys13 - C-terminal amidation
Origin	Batozonellus maculifrons (Solitary wasp)

Synonyms	beta-PMTX
Gene Id	SCN1A,SCN2A,SCN3A,SCN8A,SCN9A
Sequence	RIKIGLFDQLSRL-NH2
Target	TTX-sensitive Na+ channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Sahara, Y. et al. (2000) Eur. J. Neurosci. 12, 1961. Konno, K. et al. (2000) Neurosci. Lett. 285, 29. Konno, K. et al. (1998) Biochem. Biophys.Res. Commun. 250, 612. Sahara, Y. et al. (2000) Eur. J. Neurosci. 12, 1961. Konno, K. et al. (2000) Neurosci. Lett. 285, 29. Konno, K. et al. (1998) Biochem. Biophys. Res. Commun. 250, 612.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300092-1	P-180_1 mg	1 mg	$75		Add to Cart
BHP21300092-2	P-180_10 mg	10 mg	$188		Add to Cart
BHP21300092-3	P-180_25 mg	25 mg	$333		Add to Cart
BHP21300092-4	P-180_5 mg	5 mg	$129		Add to Cart

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