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Home / Proteins & Peptide

Azemiopsin

SKU : BHP21300121

An Antagonist of Muscular alpha1/beta1/gamma/delta nAChR

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Mfr.No.	STA-100, STA-100_0.1 mg, STA-100_0.5 mg, STA-100_1 mg
Description	An Antagonist of Muscular alpha1/beta1/gamma/delta nAChR
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C118H174N38O26
Background	Azemiopsin is a 21 amino acid peptidyl toxin, isolated from the Azemiops feae viper venom1 and is a synthetic version of the peptide. Unlike similar venom isolates, it does not contain cysteine residues1.Azemiopsin efficiently competes with alpha-Bungarotoxin (#B-100) for binding to Torpedo nAChR and with lower efficiency to human alpha7 nAChR. It dose-dependently blocks ACh-induced currents in Xenopus oocytes heterologously expressing human muscle-type nAChR and is more potent against the adult form than the fetal form1. The peptide has no effect on GABA(A) receptors or on 5-HT3 receptors1.Azemiopsin resembles Waglerin-1 (#STW-001) (a disulfide-containing peptide from the Tropidechis wagleri venom) in its biological activity.
Biological Activity	Azemiopsin blocks the adult form (alpha1/beta1/epsilon/delta) as well as the fetal form (alpha1/beta1/gamma/delta) nAChR1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2541 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	B3EWH2
Concentration	0.5 - 10 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	1391936-86-9
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Origin	Azemiops feae (Fea's viper)

Gene Id	CHRNA1,CHRNB1,CHRND,CHRNE,CHRNG
Sequence	DNWWPKPPHQGPRPPRPRPKP-OH
Target	alpha1/beta1/gamma/delta nAChR

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Utkin, Y.N. et al. (2012) J. Biol. Chem. 287, 27079. Utkin, Y.N. et al. (2012) J. Biol. Chem. 287, 27079.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300121-1	STA-100_0.1 mg	0.1 mg	$129		Add to Cart
BHP21300121-2	STA-100_0.5 mg	0.5 mg	$167		Add to Cart
BHP21300121-3	STA-100_1 mg	1 mg	$261		Add to Cart

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