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Home / Proteins & Peptide

Angiotensin III

SKU : BHP21300049

A Ligand of AT1 and AT2 G-Protein Coupled Receptors

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Mfr.No.	GPA-130, GPA-130_10 mg, GPA-130_100 mg, GPA-130_25 mg, GPA-130_5 mg, GPA-130_50 mg
Description	A Ligand of AT1 and AT2 G-Protein Coupled Receptors
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C46H66N12O9
Background	Angiotensin III (Ang III) is a hexapeptide formed from cleavage at the N-terminus of Angiotensin II (Ang II)1, a key factor in the Renin-Angiotensin-Aldosterone (RAAS) systeM In peripheral Ang systems, Ang II is the main effector peptide in the systemic circulation, although exogenous Ang III can be as potent as Ang II in, for example, stimulating aldosterone secretion2 or inhibiting renin release3. In the rat brain, Ang III was found to be equipotent with Ang II as a pressor agent or dipsogen4-7 and was bound as avidly to the nervous system as Ang II. Angiotensin receptor subtype AT1 has greater affinity towards Ang II and is also responsive to Ang III, while the AT2 receptor subtype appears to be more sensitive to Ang III but less responsive to Ang II1.
Biological Activity	Angiotensin III is an endogenous ligand of the AT1 and AT2 receptors and like Angiotensin II, regulates blood vessel tonus, blood pressure, and salt and water balance1-2.
Formulation	Lyophilized Powder.
Molecular Weight	931.1 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P01019
Concentration	1 nM - 1 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: No
Cas Number	13602-53-4
UNSPSC Code	12352202
Lead Time	1-2 Business Days

Synonyms	Ang III, Angiotensin-3, des-As1-angiotensin II
Gene Id	AGTR1, AGTR2
Sequence	RVYIHPF-OH
Target	Angiotensin II receptors

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Western blot

Reference	Wright, JW. et al. (2011) Prog. Neurobiol. 95, 49. Blair-West, JR. et al. (1980) J. Endocrinol. 87, 409. Fei, DT. et al. (1980) Life Sci. 27, 1495. Fink, GD. et al. (1985) Am. J. Physiol. Endocrinol. Metab. 249, E201. Jensen, LL. et al. (1989) Brain Res. 490, 48. Wright, JW. et al. (1985) Am. J. Physiol.Regulatory Integrative Comp. Physiol. 249, R514. Wright, JW. et al. (1989) Am. J. Physiol.Regulatory Integrative Comp. Physiol. 257, R1551. Devynck, M. A. et al. (1977) Proc. Natl. Acad. Sci. U.S.A. 74, 4092. Reaux, A. et al. (2001) Trends Endocrinol. Metabol. 12, 157.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300049-1	GPA-130_10 mg	10 mg	$50		Add to Cart
BHP21300049-2	GPA-130_100 mg	100 mg	$213		Add to Cart
BHP21300049-3	GPA-130_25 mg	25 mg	$92		Add to Cart
BHP21300049-4	GPA-130_5 mg	5 mg	$31		Add to Cart
BHP21300049-5	GPA-130_50 mg	50 mg	$134		Add to Cart

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