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Home / Proteins & Peptide

Angiotensin A (1-8)

SKU : BHP21300107

A Potent Agonist of Angiotensin II Receptors

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Mfr.No.	SPA-105, SPA-105_10 mg, SPA-105_25 mg, SPA-105_5 mg
Description	A Potent Agonist of Angiotensin II Receptors
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C49H71N13O10
Background	Angiotensin A (1-8) is an angiotensin II derivative, a vasoconstrictor peptide of the renin-angiotensin system (RAS) that acts as an angiotensin receptor type 1 and 2 (AT1R and AT2R) agonist.This peptide was first discovered in the human plasma and the sole difference between Ang A and Ang II is Ala1 residue instead of Asp1. Ang A is synthesized by enzymatic decarboxylation of Asp1 of the Ang II sequence1.Angiotensin I is metabolized to the vasoconstricting octapeptide angiotensin II by a circulating converting enzyme (ACE) by removal of two C-terminal residues. It's a natural hormone which the body produces in order to maintain normal regulation of cardiovascular function.Ang II is a primary effector peptide of the RAS in a variety of tissues and is a major target for blood pressure lowering drugs2.Studies show that Ang A has the ability to elicit pressor and renal vasoconstrictor responses in normotensive and hypertensive rats. In isolated perfused rat kidney, the peptide causes a vasoconstrictive effect dependent on AT1 receptors1.
Biological Activity	An Angiotensin II Type 1 and Type 2 Receptor Agonist1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	1002 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Concentration	0.5 - 1 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: No
Cas Number	51833-76-2
UNSPSC Code	12352202
Lead Time	1-2 Business Days

Gene Id	AGTR1, AGTR2
Sequence	ARVYIHPF-OH
Target	Angiotensin receptors

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Aequorin functional assay, Calcium imaging assay

Reference	Coutinho, D.C. et al. (2013) J. Renin Angiotensin Aldosterone Syst. 15, 480. Brasch, H. et al. (1993) Hypertension 22, 699. Coutinho, D.C. et al. (2013) J. Renin Angiotensin Aldosterone Syst. 15, 480.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300107-1	SPA-105_10 mg	10 mg	$134		Add to Cart
BHP21300107-2	SPA-105_25 mg	25 mg	$297		Add to Cart
BHP21300107-3	SPA-105_5 mg	5 mg	$85		Add to Cart

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