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Home / Proteins & Peptide

alpha-MSH

SKU : BHP21300061

A Ligand of Melanocortin G-Protein Coupled Receptor

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Mfr.No.	GPM-100, GPM-100_1 mg, GPM-100_10 mg, GPM-100_25 mg, GPM-100_5 mg
Description	A Ligand of Melanocortin G-Protein Coupled Receptor
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C77H109N21O19S
Background	alpha-MSH is a neuropeptide originally isolated from the pituitary gland1. alpha-MSH is produced by post-translational processing of a precursor protein, proopiomelanocortin (POMC)2. In most vertebrates but not in mammals, alpha-MSH is produced in the intermediate lobe of the pituitary gland. The biological activities of alpha-MSH are mediated through a family of five specific G-protein coupled receptors: MCR1, MCR2, MCR3, MCR4, and MCR5. alpha-MSH is an evolutionarily highly conserved peptide action that induces pigment dispersion in skin melanocytes of amphibians, reptiles and mammals by stimulating melanin production3,4.However, in human and other mammals, alpha-MSH acts in the brain in appetite suppression and sexual arousal. Some cases of extreme obesity have been traced to mutated alpha-MSH receptor in the brain. Presumably, these people are unable to respond to the appetite-suppressing effect of alpha-MSH5. alpha-MSH has significant anti-inflammatory properties, mediated through its binding to MCR16 and includes regulation of expression and secretion of chemokines, downregulation of proinflammatory signal-induced NF-kB activation and adhesion molecule expression, prostaglandin E2 synthesis, as well as induction of interleukin-107.
Biological Activity	alpha-MSH is involved in food intake regulation, energy homeostasis, immune responses modulation and photoprotection1-3.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	1665 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Concentration	30 - 300 pM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: No
Cas Number	0581-05-05
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Ser1- Acetylation Val13- C-terminal amidation

Synonyms	alpha-Melanotropin, alpha-MSH
Gene Id	MC1R, MC2R, MC3R, MC4R, MC5R
Sequence	SYSMEHFRWGKPV-NH2
Target	Melanocortin receptor

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Melanin production assay

Reference	Pritchard, L.E, and White, A. (2007) Endocrinology 148, 4201. Nakanishi, S. et al. (1979) Nature 278, 423. Tsatmali, T. et al. (2002) J. Histochem. Cytochem. 50, 125. Bloomgarden, Z. T. (2002) Diabetes Care. 25, 789. Catania, A. et al. (2004) Pharmacol. Rev. 56, 1. Böhm, M. et al. (2006) Cell. Mol. Biol. 52, 61. Lerner, A.B. et al. (1954) AMA Arch. Derm. Syphilol. 70, 669. Yeo, G.S. et al. (2000) QJM 93, 7. Ohguchi, K. et al. (2004) J. Biol. Chem. 279, 3408. Slominski, A. and Wortsman, J. (2000) Endocr. Rev. 21, 457.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300061-1	GPM-100_1 mg	1 mg	$55		Add to Cart
BHP21300061-2	GPM-100_10 mg	10 mg	$261		Add to Cart
BHP21300061-3	GPM-100_25 mg	25 mg	$562		Add to Cart
BHP21300061-4	GPM-100_5 mg	5 mg	$167		Add to Cart

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