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Home / Proteins & Peptide

alpha-Conotoxin PeIA

SKU : BHP21300198

An Antagonist of nAChR and N-Type Ca2+ Channels

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Mfr.No.	STC-970, STC-970_0.1 mg, STC-970_0.5 mg, STC-970_1 mg, STC-970_5 mg
Description	An Antagonist of nAChR and N-Type Ca2+ Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C65H98N22O21S4
Background	alpha-Conotoxin PeIA is a peptide toxin originally isolated from the Conus pergrandis (Grand cone) venom1. This toxin belongs to the alpha-Conotoxin family which acts on the postsynaptic membrane by binding and inhibiting nicotinic acetylcholine receptors (nAChR)1.It potently and reversibly blocks alpha9/alpha10 nAChR (IC50 = 6.9 nM) and alpha3/beta2 (IC50 = 23 nM) and discriminates between rat alpha9/alpha10 and alpha7 nACh receptors1. It also inhibits N-type Ca2+ channels (CaV2.2) (IC50 = 1.1 nM) via the activation of the GABA(B) G-protein coupled receptor in DRG neurons2.
Biological Activity	alpha-Conotoxin PeIA blocks alpha9/alpha10 and alpha3/beta2 nAChR1. Also inhibits N-type Ca2+ channels2.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	1652 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	Q1L777
Concentration	20 - 50 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	866876-88-2
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys2-Cys8 and Cys3-Cys16 Cys16 - C-terminal amidation
Origin	Conus pergrandis (Grand cone)

Synonyms	Alpha-conotoxin PeIA
Gene Id	CACNA1B,CHRNA10,CHRNA3,CHRNA6,CHRNA9,CHRNB2,CHRNB3,CHRNB4
Sequence	GCCSHPACSVNHPELC-NH2
Target	nAChR, CaV2.2 Ca2+ channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	McIntosh, J.M. et al. (2005) J. Biol. Chem. 280, 30107. Daly, N.L. et al. (2011) J. Biol. Chem. 286, 10233.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300198-1	STC-970_0.1 mg	0.1 mg	$85		Add to Cart
BHP21300198-2	STC-970_0.5 mg	0.5 mg	$235		Add to Cart
BHP21300198-3	STC-970_1 mg	1 mg	$333		Add to Cart
BHP21300198-4	STC-970_5 mg	5 mg	$1148		Add to Cart

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