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Home / Proteins & Peptide

alpha-Conotoxin MI

SKU : BHP21300163

A Potent Antagonist of Muscle alpha1/beta1/gamma/delta nAChR

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Mfr.No.	STC-370, STC-370_0.1 mg, STC-370_0.5 mg, STC-370_1 mg, STC-370_10 mg, STC-370_5 mg
Description	A Potent Antagonist of Muscle alpha1/beta1/gamma/delta nAChR
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C58H88N22O17S4
Background	alpha-Conotoxin MI is a 14 amino acid peptidyl toxin isolated from the Conus magus (Magus cone, Magician's cone snail venom)1. It acts on postsynaptic membranes on muscles and blocks mammalian nicotinic ACh channel receptor composed of alpha1/delta subunits with high potency and alpha1/gamma with a low potency2.Structure activity relationship studies were done in order to map the major amino acids in alpha-Conotoxin MI and the overall results show that primarily hydrophobic interactions stabilize the complex between the toxin and the alpha-delta interface of the nAChR3. Proline-6 and Tyrosine-12 dramatically reduced toxin potency at the high-affinity alpha/delta site while having comparatively little effect on low-affinity alpha/gamma binding4.
Biological Activity	alpha-Conotoxin MI reversibly blocks fetal muscle alpha1/beta1/gamma/delta nicotinic ACh receptor1,2,3.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	1493.7 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P01521
Concentration	2 - 20 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	83481-45-2
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys3-Cys8, Cys4-Cys14 Cys14 - C-terminal amidation
Origin	Conus magus (Magical cone)

Synonyms	alpha-MI, CtxMI, M1
Gene Id	CHRNA1,CHRNB1,CHRND,CHRNG
Sequence	GRCCHPACGKNYSC-NH2
Target	alpha1/beta1/gamma/delta nAChR

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	McIntosh, M. et al. (1982) Arch. Biochem. Biophys. 218, 329. Marshall, I.G. and Harvey, A.L. (1990) Toxicon 28, 231. Bren, N. and Sine, S.M. (2000) J. Biol. Chem. 275, 12692. Jacobsen, R.B. et al. (1999) Biochemistry 38, 13310. McIntosh, M. et al. (1982) Arch. Biochem. Biophys. 218, 329. Bren, N. and Sine, S.M. (2000) J. Biol. Chem. 275, 12692. Jacobsen, R.B. et al. (1999) Biochemistry 38, 13310.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300163-1	STC-370_0.1 mg	0.1 ml	$117		Add to Cart
BHP21300163-2	STC-370_0.5 mg	0.5 mg	$168		Add to Cart
BHP21300163-3	STC-370_1 mg	1 mg	$219		Add to Cart
BHP21300163-4	STC-370_10 mg	10 mg	$916		Add to Cart
BHP21300163-5	STC-370_5 mg	5 mg	$655		Add to Cart

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