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Home / Proteins & Peptide

alpha-Conotoxin ImI

SKU : BHP21300031

A Potent Antagonist of Mammalian alpha3/beta2 Neuronal nAChR

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Mfr.No.	C-290, C-290_0.1 mg, C-290_0.5 mg, C-290_1 mg, C-290_10 mg, C-290_5 mg
Description	A Potent Antagonist of Mammalian alpha3/beta2 Neuronal nAChR
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C52H78N20O15S4
Background	alpha-Conotoxin ImI is a 12 amino acid peptidyl toxin isolated from Conus Imperialis venom1, which blocks mammalian neuronal nAChRs located on postsynaptic membranes. This toxin inhibits mammalian neuronal nAChRs (alpha3/beta2 > alpha7 > alpha3/beta4) in a voltage-independent manner and has no effect on nAChRs composed of alpha2/beta2, alpha3/beta2, alpha4/beta2, alpha2/beta4, alpha3/beta4, or alpha4/beta4 subunits1,2.
Biological Activity	alpha-Conotoxin ImI potently and specifically blocks mammalian neuronal nAChR (alpha3/beta2 > alpha7 > alpha3/beta4)1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	1351 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P50983
Concentration	0.1 - 10 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	156467-85-5
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys2-Cys8 and Cys3-Cys12 Cys12 - C-terminal amidation
Origin	Conus imperialis (Imperial cone)

Synonyms	alpha-CTx ImI
Gene Id	CHRNA3,CHRNA7 ,CHRNB2,CHRNB4
Sequence	GCCSDPRCAWRC-NH2
Target	alpha3/beta2 nAChR

Country Of Origin	Israel/IL
Purity	>=99% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	McIntosh, J.M. et al. (1994) J. Biol. Chem. 269, 16733. Johnson, D.S. et al. (1995) Mol. Pharmacol. 48, 194. McIntosh, J.M. et al. (1994) J. Biol. Chem. 269, 16733.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300031-1	C-290_0.1 mg	0.1 mg	$117		Add to Cart
BHP21300031-2	C-290_0.5 mg	0.5 mg	$168		Add to Cart
BHP21300031-3	C-290_1 mg	1 mg	$235		Add to Cart
BHP21300031-4	C-290_10 mg	10 mg	$1307		Add to Cart
BHP21300031-5	C-290_5 mg	5 mg	$818		Add to Cart

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