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Home / Proteins & Peptide

alpha-Conotoxin EIIB

SKU : BHP21300157

A Potent Antagonist of alpha1/beta1/delta/gamma nAChR

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Mfr.No.	STC-230, STC-230_0.1 mg, STC-230_0.5 mg, STC-230_1 mg, STC-230_5 mg, STC-230_50 mcg
Description	A Potent Antagonist of alpha1/beta1/delta/gamma nAChR
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C71H103N25O20S4
Background	alpha-Conotoxin EIIB is a peptide toxin originally isolated from Conus ermineus (Atlantic fish-hunting cone) venoM It is a potent alpha1/beta1/delta/gamma nicotinic acetylcholine receptor antagonist and displays a Ki of 2.2 ± 0.7 nM1. The peptide toxin is stabilized by six hydrogen bonds and disulfides between residues 2 and 7 and 3 and 132.Nicotinic acetylcholine receptors (nAChRs) are ionotropic multisubunit, neurotransmitter-gated receptors of the cholinergic systeM They are assembled from one or more alpha subunits (alpha1-alpha10) alone or together with one or more beta subunits (beta1-beta4)3. Other subunits also co-assemble in the formation of the receptor channel.
Biological Activity	alpha-Conotoxin EIIB is a potent alpha1/beta1/delta/gamma nAChR antagonist1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	1754.5 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	C0HKF6
Concentration	1 - 50 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys5-11, Cys6-16 Cys16 - C-terminal amidation Pro3 - Hydroxyproline Pyrrolidone carboxylic acid (Glp) E1 - Pyrrolidone carboxylic acid (Glp)
Origin	Conus ermineus (Agate cone) (Chelyconus ermineus)

Synonyms	Alpha-conotoxin EIIB
Gene Id	CHRNA1,CHRNB1,CHRND,CHRNG
Sequence	ETPGCCWHPACGKNRC-NH2
Target	Muscle nAChR

Country Of Origin	Israel/IL
Purity	>=99% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Benie, A.J. et al. (2000) FEBS Lett. 476, 287. Lustig, L.R. et al. (2006) Anat. Rec. A Discov. Mol. Cell. Evol. Biol. 288, 424. Echterbille, J. et al. (2017) Toxicon 130, 1. Echterbille, J. et al. (2017) Toxicon 130, 1.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300157-1	STC-230_0.1 mg	0.1 mg	$117		Add to Cart
BHP21300157-2	STC-230_0.5 mg	0.5 mg	$202		Add to Cart
BHP21300157-3	STC-230_1 mg	1 mg	$287		Add to Cart
BHP21300157-4	STC-230_5 mg	5 mg	$981		Add to Cart
BHP21300157-5	STC-230_50 mcg	50 mcg	$85		Add to Cart

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