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Home / Proteins & Peptide

alpha-Conotoxin EI

SKU : BHP21300196

An Antagonist of alpha1/beta1/gamma/delta nAChR

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Mfr.No.	STC-900, STC-900_0.1 mg, STC-900_0.5 mg, STC-900_1 mg, STC-900_10 mg, STC-900_5 mg
Description	An Antagonist of alpha1/beta1/gamma/delta nAChR
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C83H125N27O27S5
Background	The nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion channels that are widely expressed throughout the central and peripheral nervous systems. The best characterized nAChR is the receptor at the neuromuscular junction, with four different subunits in a pentameric array, (alpha1)2beta1gammadelta1.Small peptide toxins of Conus origin known as the Aalpha-conotoxins are highly useful tools for exploring ligand nAChR interactions. alpha-Conotoxins are known to be selective and potent competitive antagonists of nicotinic acetylcholine receptors2.alpha-Conotoxin EI is a 18 amino acid peptidyl toxin, originally isolated from the Conus ermineus (Athlantic fish-hunting cone) venoM In Torpedo nAChRs, alpha-conotoxin EI selectively binds the agonist site near the alpha/delta subunit interface. In mammalian nAChRs alpha-conotoxin EI shows high affinity for both the alpha/delta and alpha/gamma subunit interfaces (with some preference for the alpha/delta site)3.The unique binding preference of alpha-conotoxin EI to the alpha/delta subunit interface makes it a valuable structural template for superposition of various alpha-conotoxin possessing distinct receptor subtype specificities4.
Biological Activity	A selective blocker of alpha1/beta1/gamma/delta nAChR.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2093.4 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P50982
Concentration	500 nM - 1 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	170663-33-9
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys4-Cys10, Cys5-Cys18 Cys18 - C-terminal amidation X = Hydroxyproline
Origin	Conus ermineus (Agate cone) (Chelyconus ermineus)

Synonyms	Alpha-conotoxin EI
Gene Id	CHRNA1,CHRNA3,CHRNA4,CHRNA7, CHRNB1,CHRNB2,CHRNB4,CHRND,CHRNG
Sequence	RDXCCYHPTCNMSNPQIC-NH2
Target	alpha1/beta1/gamma/delta nAChR

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	McIntosh, J.M. et al. (1999) Annu. Rev. Biochem. 68, 59. Martinez, J.S. et al. (1995) Biochemistry 34, 14519. Park, K.H. et al. (2001) J. Biol. Chem. 276, 49028. McGehee, D.S. and Role L.W. (1995) Annu. Rev. Physiol. 57, 521. Martinez, J.S. et al. (1995) Biochemistry 34, 14519.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300196-1	STC-900_0.1 mg	0.1 mg	$132		Add to Cart
BHP21300196-2	STC-900_0.5 mg	0.5 mg	$266		Add to Cart
BHP21300196-3	STC-900_1 mg	1 mg	$383		Add to Cart
BHP21300196-4	STC-900_10 mg	10 mg	$1227		Add to Cart
BHP21300196-5	STC-900_5 mg	5 mg	$768		Add to Cart

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