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Home / Proteins & Peptide

alpha-Conotoxin BuIA

SKU : BHP21300143

A Potent alpha6/alpha3beta2beta3 and alpha3beta2 nAChRs Antagonist

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Mfr.No.	STC-030, STC-030_0.1 mg, STC-030_0.5 mg, STC-030_1 mg, STC-030_10 mg, STC-030_5 mg
Description	A Potent alpha6/alpha3beta2beta3 and alpha3beta2 nAChRs Antagonist
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C54H82N14O16S4
Background	alpha-Conotoxin BuIA is a 13 amino acid peptidyl toxin that was originally isolated from the fish-eating snail, Conus bullatus1. This toxin exhibits strong antagonistic activity at alpha6/alpha3beta2beta3, alpha3beta2, and alpha3beta4 nicotinic acetylcholine receptors (nAChRs) and has the unique ability to kinetically discriminate between the beta2 and beta4-containing receptor subtypes, as the off-rates are rapid for beta2-subunit, but very slow for beta4-containing nAChRs. alpha-Conotoxin BuIA is a member of the A-superfamily of conotoxins and possess an unusual 4/4 disulfide scaffold. This toxin appears to be a valuable probe to distinguish among nAChRs containing different alpha and beta subunits1-4.nAChRs are pentameric ligand-gated ion channels that are critically important for neuronal survival and cognitive function, as well as regulation of neurodegenerative diseases, including Alzheimer's and Parkinson's. The nAChR subtypes share a common basic structure, but their biophysical and pharmacological properties depend on their subunit composition. Thus, the subunit makeup of the nAChR subtypes is central to understanding their function in the nervous system and for discovering new subtype-selective drugs5-7.
Biological Activity	A potent alpha6/alpha3beta2beta3, alpha3beta2, and alpha3beta4 nAChRs blocker with a unique ability to kinetically discriminate between the beta2 and beta4-containing receptor subtypes1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	1311.6 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P69657
Concentration	10 - 50 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys2-Cys8, Cys3-Cys13 Cys13 - C-terminal amidation
Origin	Conus bullatus (Bubble cone)

Synonyms	Conotoxin Bu1.3, BuIA, Alpha-conotoxin BuIA
Gene Id	CHRNA6,CHRNA3,CHRNB2,CHRNB4,CHRNA4,CHRNA2, CHRNA7
Sequence	GCCSTPPCAVLYC-NH2
Target	alpha6/alpha3beta2beta3, alpha3beta2, and alpha3beta4 nAChRs

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Azam, L. et al. (2005) J Biol Chem., 280, 80. Chi, S-W. et al. (2006) Biochem. Biophys. Res. Commun., 349, 1228. Kim, H-W. and McIntosh, J.M. et al. (2012) FASEB J., 26, 4102. Shiembob, D. L. et al. (2006) Biochemistry, 2006, 45, 11200. Zoli, M. et al. (2015) Neuropharmacology, 96, 302. Gotti, C. et al. (2009) Biochem. Pharmacol., 78, 703. Levin, E. D. et al. (2006) Psychopharmacology, 184, 523. Azam, L. et al. (2005) J Biol Chem., 280, 80.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300143-1	STC-030_0.1 mg	0.1 mg	$75		Add to Cart
BHP21300143-2	STC-030_0.5 mg	0.5 mg	$152		Add to Cart
BHP21300143-3	STC-030_1 mg	1 mg	$273		Add to Cart
BHP21300143-4	STC-030_10 mg	10 mg	$1731		Add to Cart
BHP21300143-5	STC-030_5 mg	5 mg	$1082		Add to Cart

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