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Home / Proteins & Peptide

alpha-Bungarotoxin

SKU : BHP21300001

A Potent Antagonist of alpha7 and Muscle nAChR and GABA(A) Receptor Subtypes

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Mfr.No.	B-100, B-100_0.5 mg, B-100_1 mg, B-100_10 mg, B-100_5 mg
Description	A Potent Antagonist of alpha7 and Muscle nAChR and GABA(A) Receptor Subtypes
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C338H529N97O105S11
Background	alpha-Bungarotoxin isoform A31 is a 74 amino acid peptidyl toxin isolated from the venom of the banded krait snake, Bungarus multicinctus1.alpha-Bungarotoxin blocks postsynaptic neuromuscular transmission via competitive inhibition of nicotinic ACh receptors (nAChRs) with an IC50 of 3.5 x 10-10 M, thereby preventing the depolarizing action on postsynaptic membranes and blocking neuromuscular transmission2.The toxin is selective for alpha7 receptors (IC50 value of 1.6 nM) and alpha3/beta4 receptors (IC50 value of >3 uM)3,4.alpha-Bungarotoxin also binds to and blocks a subset of GABAA receptors (GABAARs) that contain the GABAAR beta3 subunit. In particular, alpha-Bungarotoxin blocks GABAARs that contain interfaces between adjacent beta3 subunits5.
Biological Activity	alpha-Bungarotoxin blocks postsynaptic neuromuscular transmission via competitive inhibition of nicotinic ACh receptors (nAChRs), thereby preventing the depolarizing action on postsynaptic membranes and blocking neuromuscular transmission. Selective for alpha7 receptors (IC50 value of 1.6 nM) and alpha3/beta4 receptors (IC50 value of >3 uM)1,2. The toxin also blocks GABA(A) receptor subtypes3.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	7984 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Natural protein
Accession Number	P60615
Concentration	1 nM - 3 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Cited Application: Electrophysiology Is Toxin: Yes
Cas Number	11032-79-4
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys3-Cys23, Cys16-Cys44, Cys29-Cys33, Cys48-Cys59 and Cys60-Cys65
Origin	Bungarus multicinctus (Many-banded krait)

Synonyms	Long neurotoxin 1, alpha-Bgtx, alpha-BuTX
Gene Id	CHRNA1,CHRNA10,CHRNA7,CHRNA9,CHRNB1,GABRA1,GABRA2,GABRA4,GABRA5,GABRB2,GABRB3,GABRG2
Sequence	IVCHTTATSPISAVTCPPGENLCYRKMWCDAFCSSRGKVVELGCAATCPSKKPYEEVTCCSTDKCNPHPKQRPG-OH
Target	alpha7, alpha1/beta1/gamma/delta nAChR, GABA(A) receptor subtypes

Country Of Origin	Israel/IL
Purity	>=99% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Ohta, M. et al. (1987) FEBS Lett. 222, 79. Wilson, P.T. et al. (1988) Mol. Pharmacol. 34, 643. Wilson, S.P. and Kirshner, N. (1977) J. Neurochem. 28, 687. Garcia-Guzman, M. et al. (1995) Eur. J. Neurosci. 7, 647. McCann, C.M. et al. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 5149. Wilson, S.P. and Kirshner, N. (1977) J. Neurochem. 28, 687. Garcia-Guzman, M. et al. (1995) Eur. J. Neurosci. 7, 647. McCann, C.M. et al. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 5149.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300001-1	B-100_0.5 mg	0.5 mg	$96		Add to Cart
BHP21300001-2	B-100_1 mg	1 mg	$142		Add to Cart
BHP21300001-3	B-100_10 mg	10 mg	$1143		Add to Cart
BHP21300001-4	B-100_5 mg	5 mg	$636		Add to Cart

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