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Home / Proteins & Peptide

AITRL, Mouse

SKU : BHP18500265

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Mfr.No.	IX03098, IX03098-1, IX03098-10, IX03098-50
Description	Activation-Inducible TNF-Related Ligand (AITRL), also known as Glucocorticoid-Induced TNF-Related Ligand (GITRL), belongs to the tumor necrosis factor superfamily (TNFSF). AITRL is a Type II single transmembrane protein and shares low conservation within the extracellular domain with other TNFSF members. AITRL is expressed on macrophages, immature and mature dendritic cells and B cells. Its receptor, Activation-Inducible TNFR family Receptor (AITR), is expressed on T lymphocytes, natural killer (NK) cells, and antigen- presenting cells. After binding by AITRL, AITR can be released. AITR activation increases resistance to tumors and viral infections and is involved in autoimmune and inflammatory processes. In addition, activated AITR increases TCR-induced T cell proliferation and cytokine production and rescues T cells and NK cells from apoptosis. Recombinant mouse Activation-Inducible TNF-Related Ligand (rmAITRL) produced in E. coli is a single non-glycosylated polypeptide chain containing 127 amino acids. A fully biologically active molecule, rmAITRL has a molecular mass of 14.5 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques.
Reconstitution	Reconstituted in ddH2O at 100 ug/mL.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	14.5 kDa, observed by reducing SDS-PAGE.
Source	E. coli
Host	Mouse
Accession Number	Q7TS55
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED50 5 ng/mL, measured by the amount of Interleukin-8 produced by PMBC, corresponding to a specific activity of 2.0 x 105 units/mg.

Synonyms	Activation-induced TNFR member Ligand, TNFSF18, GITRL, TL-6
Sequence	TAIESCMVKF ELSSSKWHMT SPKPHCVNTT SDGKLKILQSGTYLIYGQVI PVDKKYIKDN APFVVQIYKK NDVLQTLMNDFQILPIGGVY ELHAGDNIYL KFNSKDHIQK TNTYWGIILMPDLPFIS

Purity	95% by SDS-PAGE and HPLC analyses.
Storage	Lyophilized recombinant mouse Activation-Inducible TNF-Related Ligand (rmAITRL) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rmAITRL remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500265-1	IX03098-1	1mg	$2621		Add to Cart
BHP18500265-2	IX03098-10	10ug	$82		Add to Cart
BHP18500265-3	IX03098-50	50ug	$282		Add to Cart

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