HSP90 beta Protein - BHP11900004

Mfr.No.	SPR-102, SPR-102A, SPR-102B, SPR-102C
Description	Active Human Recombinant HSP90 beta Full Length Protein, Active Human Recombinant HSP90 beta Full Length Protein
Alternative Names	FLJ26984 Protein, HSP84 Protein, HSP90 Protein, HSP90B Protein, HSPC2 Protein, HSPCB Protein
Biological Activity	ATPase active
Cellular Localization	Cytoplasm, Melanosome
Certificate Of Analysis	This product has been certified >90% pure using SDS-PAGE analysis.
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Regulatory	RUO
Scientific Background	HSP90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. From a functional perspective, HSP90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex (1-4). Despite its label of being a heat-shock protein, HSP90 is one of the most highly expressed proteins in unstressed cells (12% of cytosolic protein). It carries out a number of housekeeping functions including controlling the activity, turnover, and trafficking of a variety of proteins. Most of the HSP90-regulated proteins that have been discovered to date are involved in cell signaling (5-6). The number of proteins now know to interact with HSP90 is about 100. Target proteins include the kinases v-Src, Wee1, and c-Raf, transcriptional regulators such as p53 and steroid receptors, and the polymerases of the hepatitis B virus and telomerase.5. When bound to ATP, HSP90 interacts with co-chaperones Cdc37, p23, and an assortment of immunophilin-like proteins, forming a complex that stabilizes and protects target proteins from proteasomal degradation. In most cases, HSP90-interacting proteins have been shown to co-precipitate with HSP90 when carrying out immunoadsorption studies, and to exist in cytosolic heterocomplexes with it. In a number of cases, variations in HSP90 expression or HSP90 mutation has been shown to degrade signaling function via the protein or to impair a specific function of the protein (such as steroid binding, kinase activity) in vivo. Ansamycin antibiotics, such as geldanamycin and radicicol, inhibit HSP90 function (7). Looking for more information on HSP90 Visit our new HSP90 Scientific Resource Guide at http://www.HSP90.ca.
Species	Human
Specificity	~90 kDa
Accession Number	NP_031381.2
Concentration	Lot/batch specific. See included datasheet.
Purification	Affinity Purified, Low Endotoxin, Affinity Purified, Low Endotoxin
Expression System	Baculovirus/Sf9 cells
Amino Acid Sequence	MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD
Bioactivity	ATPase active
Biological Activity Abreviation	Active
Biological Activity Comment	ATPase active
Cite This Product	Human Recombinant HSP90 beta Protein (StressMarq Biosciences, Canada, Cat # SPR-102A)
Mol Weight	~90 kDa
Nature	Recombinant
Protein Length	Full Length

Gross Weight (kg)	1.4
Launch Date	2008/11/01
Net Weight (g)	0.05
Number Of Pubmed Citations	9
Swissprot	P08238
Target Details	HSP90 beta
Gene Id	3326
Research Area	Cancer, Heat Shock, Cell Signaling, Chaperone Proteins, Tumor Biomarkers, Protein Trafficking
Target	HSP90 beta

Adr Code	Non-hazardous
Country Of Origin	Canada
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Published Application	Functional Assay ; ELISA ; Functional Assay ; Functional Assay ; Functional Assay ; ELISA ; Immunoprecipitation ; Immunoprecipitation ; Surface Plasmon Resonance Spectroscopy
Published Species Reactivity	Human ; Human ; Human ; Human ; Human ;
Pubmed Id	28558721 ; 28495207 ; 28302086 ; 28346089 ; 27110679 ; 26553996 ; 24466266 ; 24098578 ; 22271514
Shipping	Blue Ice or 4ºC
Stock Product	Y
Tarriff Code	3822.19.0030
Un Code For Transport	Non-hazardous
Unspsc Code	12352202
Shipping Temperature	Blue Ice or 4°C
Buffer	20mM Tris, pH7.5, 175 mM NaCl, 0.1 mM EDTA, 10% glycerol, 1 mM DTT
Description	Accession Number: NP_031381.2 Specificity: ~90 kDa Certificate of Analysis: This product has been certified >90% pure using SDS-PAGE analysis. Country of Origin: Canada Gross Weight (kg): 1.4 Net Weight (g): 0.05 Stock Product: Y
Purity	>85%
Storage Buffer	20mM Tris, pH7.5, 175 mM NaCl, 0.1 mM EDTA, 10% glycerol, 1 mM DTT
Storage Temperature	-20°C

Immunogen Species	Homo Sapiens (Human)
Applications	Functional assay, Surface Plasmon Resonance, WB, Co-IP, ELISA, SDS-PAGE

Reference	1. Arlander S.J.H., et al. (2003) J Biol Chem. 278: 52572-52577. 2. Pearl H., et al. (2001) Adv Protein Chem. 59:157-186. 3. Neckers L., et al. (2002) Trends Mol Med. 8:S55-S61. 4. Pratt W., Toft D. (2003) Exp Biol Med. 228:111-133. 5. Pratt W., Toft D. (1997) Endocr Rev. 18: 306360. 6. Pratt W.B. (1998) Proc Soc Exptl Biol Med. 217: 420434. 7. Whitesell L., et al. (1994) Proc Natl Acad Sci USA. 91: 8324 8328.

Product Manual	Datasheet
SDS

Have you used this product?

Rate it now..!!

Combination SKU	Supplier No.	Size	Your price
BHP11900004-1	SPR-102A	50 ug	$167	Add to Cart
BHP11900004-2	SPR-102B	100 ug	$283	Add to Cart
BHP11900004-3	SPR-102C	100 ug x2	$398	Add to Cart

Active Human Recombinant HSP90 beta Full Length Protein

Contact us to order

Tel

Email

Contact us to order

Tel

Email

Reviews of Active Human Recombinant HSP90 beta Full Length Protein

Rate it now..!!