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Home / Proteins & Peptide

1Kalpha²-Pompilidotoxin

SKU : BHP21300093

An Activator of NaV Channels

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Mfr.No.	P-182, P-182_1 mg, P-182_10 mg, P-182_5 mg
Description	An Activator of NaV Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C71H124N20O17
Background	1Kbeta-PMTX is a mutated form of the beta-PMTX (#P-180), originally isolated from the solitary wasp (Batozonellus maculifrons) venom and is a synthetic version of the peptide1. Pompilidotoxins (PMTX, alpha and beta) are small peptides consisting of 13 amino acids.beta-PMTX induces a unique pattern of repetitive action potentials previous seen with other neurotoxins and thus facilitates both excitatory and inhibitory synaptic transmission.Recently it was found that this toxin slows the Na+-channel inactivation, without changing the peak current-voltage relationship or the activation time course of the TTX-sensitive Na+ currents in the neuromuscular synapse of the lobster walking leg and in the rat trigeminal ganglion neurons2-4. It is effective at concentrations of 10 nM in cultured rat cortical neurons5.1Kbeta-PMTX is mutated at position 1 with Arginine to Lysine transition, which enhances its activity on voltage-gated human Nav1.6 Na+ channels relative to native beta-PMTX1,3.
Biological Activity	1Kbeta-PMTX slows NaV channel inactivation without changing the peak current-voltage relationship or the activation time course of the TTX-sensitive Na+ currents in the neuromuscular synapse1-3. 1Kbeta-PMTX showed the largest effects on the various tested NaV isoforms, mainly on NaV1.6 channels1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	1530 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Concentration	100 - 200 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Leu13 - C-terminal amidation
Origin	Batozonellus maculifrons (Solitary wasp)

Synonyms	1Kbeta-PMTX
Gene Id	SCN1A, SCN2A, SCN3A, SCN8A, SCN9A
Sequence	KIKIGLFDQLSRL-NH2
Target	NaV Na+ channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Schiavon, E. et al. (2010) FEBS J. 277, 918. Sahara, Y. et al. (2000) Eur. J. Neurosci. 12, 1961. Konno, K. et al. (2000) Neurosci. Lett. 285, 29. Konno, K. et al. (1998) Biochem. Biophys. Res. Commun. 250, 612. Harsch, A. et al. (1998) Neurosci. Lett. 252, 49. Schiavon, E. et al. (2010) FEBS J. 277, 918. Sahara, Y. et al. (2000) Eur. J. Neurosci. 12, 1961. Konno, K. et al. (2000) Neurosci. Lett. 285, 29.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300093-1	P-182_1 mg	1 mg	$75		Add to Cart
BHP21300093-2	P-182_10 mg	10 mg	$188		Add to Cart
BHP21300093-3	P-182_5 mg	5 mg	$129		Add to Cart

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