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Home / Proteins & Peptide

[Y]6-Angiotensin II Analog

SKU : BHP21300111

A Potent and Selective AT2R Agonist

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Mfr.No.	SPA-175, SPA-175_0.1 mg, SPA-175_0.5 mg, SPA-175_1 mg, SPA-175_10 mg, SPA-175_5 mg
Description	A Potent and Selective AT2R Agonist
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C53H73N11O13
Background	Y6-Angiotensin II Analog is a potent and selective agonist of Angiotensin II type 2 receptor (AT2R)1. Studies show that it can be used as a safe and effective therapeutic tool for pancreatic ductal adenocarcinoma1.Local administration of Y6-Angiotensin II Analog causes AT2R gene expression in tumor cells and significantly attenuates the growth of fast growing murine pancreatic ductal adenocarcinoma tumors. This evidence may suggest that AT2R agonist therapy is an effective and useful procedure for pancreatic ductal adenocarcinoma treatment2.Y6-Angiotensin II Analog shows two distinct sets of proton resonances in aqueous solution, cis and trans conformations1. The cis isomer contains aromatic rings of Tyr6 and Phe8 stacked around the Pro7 ring, thus leading to a compact hydrophobic motif1.Angiotensin II type 2 receptor belongs to the superfamily of G-protein coupled receptors. The receptor mediates angiotensin II actions involved in vasodilation and anti-proliferation2.
Biological Activity	Y6-Angiotensin Analog is an AT2R agonist1,2.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	1072 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Concentration	1 - 100 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: No
UNSPSC Code	12352202
Lead Time	1-2 Business Days

Gene Id	AGTR2
Sequence	DRVYIYPF-OH
Target	AT2 receptor

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Western blot

Reference	Magnani, F. et al. (2014) ACS Chem. Biol. 9, 1420. Ishiguro, S. et al. (2015) Cancer Biol. Ther. 16, 307.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300111-1	SPA-175_0.1 mg	0.1 mg	$117		Add to Cart
BHP21300111-2	SPA-175_0.5 mg	0.5 mg	$401		Add to Cart
BHP21300111-3	SPA-175_1 mg	1 mg	$642		Add to Cart
BHP21300111-4	SPA-175_10 mg	10 mg	$2959		Add to Cart
BHP21300111-5	SPA-175_5 mg	5 mg	$2238		Add to Cart

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