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Home / Proteins & Peptide / Proteins

Urotoxin

SKU : BHP21300305

A Super Potent Blocker of KV1.2 Channel

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Mfr.No.	STU-200, STU-200_0.1 mg, STU-200_0.5 mg, STU-200_1 mg, STU-200_10 mg, STU-200_5 mg
Description	A Super Potent Blocker of KV1.2 Channel
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C161H260N52O50S9
Background	Urotoxin is a peptide toxin originally isolated from Urodacus yaschenkoi Australian Scorpion venoM Urotoxin is an extremely potent blocker of human voltage-gated potassium channel KV1.2 channels with IC50 values of 160 pM However, it also displays activity towards KV1.1, KV1.3 and KCa3.1 with IC50 values of 253 nM, 91 nM and 70 nM respectively1.Potassium channels are membrane proteins found in excitable and nonexcitable cells. KV1.2 channel plays an important role in the maintenance of resting membrane potential and the regulation of the cellular excitability of neurons1,2.
Biological Activity	Urotoxin is a potent KV1.2 channel blocker. The toxin also blocks KV1.1, KV.3 and KCa3.1 channels.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	4012.8 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P0DL37
Concentration	50 pM - 1 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys5-Cys26, Cys11-Cys31, Cys15-Cys33 and Cys21-Cys36 Val37 - C-terminal amidation
Origin	Urodacus yaschenkoi (Inland robust scorpion)

Synonyms	Potassium channel toxin alpha-KTx 6.21
Gene Id	KCNA1 ,KCNA2 ,KCNA3,KCNN4
Sequence	GDIKCSGTRQCWGPCKKQTTCTNSKCMNGKCKCYGCV-NH2
Target	KV1.2, KV1.1, KV1.3, KCa3.1 channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Luna-Ramirez K. et al. (2014) Mol. Pharmacol. 86, 28. Yuan, S. et al. (2017) Toxins (Basel) 9, 11.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300305-1	STU-200_0.1 mg	0.1 mg	$287		Add to Cart
BHP21300305-2	STU-200_0.5 mg	0.5 mg	$680		Add to Cart
BHP21300305-3	STU-200_1 mg	1 mg	$1086		Add to Cart
BHP21300305-4	STU-200_10 mg	10 mg	$4558		Add to Cart
BHP21300305-5	STU-200_5 mg	5 mg	$2849		Add to Cart

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