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Home / Proteins & Peptide / Proteins

u-Conotoxin SxIIIC

SKU : BHP21300149

A potent blocker of NaV Channels

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Mfr.No.	STC-130, STC-130_0.1 mg, STC-130_0.5 mg, STC-130_1 mg, STC-130_5 mg, STC-130_50 mcg
Description	A potent blocker of NaV Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C90H142N42O27S6
Background	u-conotoxin SxIIIC (SxIIIC) is a 22 amino acid peptidyl toxin originally isolated from the venom of the cone snail, Conus striolatus1. SxIIIC is a potent and irreversible blocker of voltage-gated sodium (Nav) channels, which displays a unique u-conotoxin selectivity profile of human (h)NaV1.4 > hNaV1.3 > hNaV1.1? hNaV1.6? hNaV1.7 > hNaV1.2 >> hNaV1.5? hNaV1.81.Voltage-gated sodium channels (VGSCs) are transmembrane proteins that control the voltage-dependent increase in sodium permeability. VGSCs play a fundamental role in normal neurological function, especially in the initiation and propagation of action potentials. Nav channels have been the topic of significant research and discussion for a considerable amount of time given their unique functions in electrical cell signaling. These channels are very important for homeostasis, thus specific genetic abnormalities in VGSC genes can result in a range of muscle, cardiac, and neurological disorders known as "channelopathies"2. Marine toxins appear to be an emerging source of therapeutic tools that can relieve pain or treat VGSC-related human channelopathies3.
Biological Activity	Mu-conotoxin SxIIIC most potently blocks NaV1.4 channel, with 10-fold selectivity over NaV1.1, 1.3, 1.6 and 1.7, 24-fold selectivity over hNaV1.2.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2437 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	A0A7M4DUE8
Concentration	15 - 200 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys3-Cys15, Cys4-Cys21 and Cys10-Cys22 Cys22 - C-terminal amidation
Origin	Conus striolatus (Cone snail)

Synonyms	Mu-conotoxin SxIIIC, SxIIIC peptide
Gene Id	SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A
Sequence	RGCCNGRGGCSSRWCRDHARCC-NH2
Target	Nav1.4, Nav1.3, Nav1.1, Nav1.6 and Nav1.7 blocker

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	McMahon, K.L. et al. (2020) Biomedicines, 8, 321. Huang, W. et al. (2017) Protein Cell, 8, 401. Mackieh, R. et al. (2021) Mar. Drugs, 19, 562. McMahon, K.L. et al. (2020) Biomedicines, 8, 321.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300149-1	STC-130_0.1 mg	0.1 mg	$449		Add to Cart
BHP21300149-2	STC-130_0.5 mg	0.5 mg	$1566		Add to Cart
BHP21300149-3	STC-130_1 mg	1 mg	$2505		Add to Cart
BHP21300149-4	STC-130_5 mg	5 mg	$8765		Add to Cart
BHP21300149-5	STC-130_50 mcg	50 mcg	$281		Add to Cart

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