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Home / Proteins & Peptide / Proteins

u-Conotoxin SIIIA

SKU : BHP21300167

A Blocker of TTX-Sensitive NaV1.2, NaV1.3 and NaV1.4 Voltage-Gated Na+ Channels

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Mfr.No.	STC-450, STC-450_0.1 mg, STC-450_0.5 mg, STC-450_1 mg, STC-450_10 mg, STC-450_5 mg, STC-450_50 mcg
Description	A Blocker of TTX-Sensitive NaV1.2, NaV1.3 and NaV1.4 Voltage-Gated Na+ Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C83H123N33O27S6
Background	u-Conotoxin SIIIA is a synthetic peptide purified to homogeneity, originally isolated from the Conus striatus venom1. u-Conotoxin SIIIA reversibly blocks TTX-sensitive voltage-gated Na+ channels in small-diameter DRG neurons.1,2 It also irreversibly blocks NaV1.2, NaV1.3 and NaV1.4 channels expressed in Xenopus oocytes in a dose- and time-dependent manner3. No inhibition is detected on NaV1.5, NaV1.7 or NaV1.8 channels4,5.
Biological Activity	u-Conotoxin SIIIA blocks TTX-sensitive voltage-gated Na+ channels in small-diameter DRG neurons1,2. It also irreversibly blocks NaV1.2, NaV1.3 and NaV1.4 channels expressed in Xenopus oocytes in a dose- and time-dependent manner3. No inhibition is detected on NaV1.5, NaV1.7 or NaV1.8 channels4,5.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2207.5 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	Q86DU6
Concentration	0.5 - 3 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys3-Cys13, Cys4-Cys19, Cys8-Cys20 Z1 - Pyrrolidone carboxylic acid (Glp) Cys20 - C-terminal amidation
Origin	Conus striatus (Striated cone)

Synonyms	Mu-conotoxin SIIIA
Gene Id	SCN1A,SCN2A,SCN3A,SCN4A,SCN8A
Sequence	ZNCCNGGCSSKWCRDHARCC-NH2
Target	NaV1.2, NaV1.3, NaV1.4 Na+ channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Bulaj, G. et al. (2005) Biochemistry 44, 7259. Wang, C.Z. et al. (2006) Toxicon 47, 122. Schroeder, C.I. et al. (2008) J. Biol. Chem. 283, 21621. Yao, S. et al. (2008) Biochemistry 47, 10940. Leipold, E. et al. (2011) Neuropharmacology 61, 105. Bulaj, G. et al. (2005) Biochemistry 44, 7259. Wang, C.Z. et al. (2006) Toxicon 47, 122. Schroeder, C.I. et al. (2008) J. Biol. Chem. 283, 21621. Yao, S. et al. (2008) Biochemistry 47, 10940. Leipold, E. et al. (2011) Neuropharmacology 61, 105.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300167-1	STC-450_0.1 mg	0.1 mg	$266		Add to Cart
BHP21300167-2	STC-450_0.5 mg	0.5 mg	$460		Add to Cart
BHP21300167-3	STC-450_1 mg	1 mg	$824		Add to Cart
BHP21300167-4	STC-450_10 mg	10 mg	$3531		Add to Cart
BHP21300167-5	STC-450_5 mg	5 mg	$2880		Add to Cart
BHP21300167-6	STC-450_50 mcg	50 mcg	$170		Add to Cart

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