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Home / Proteins & Peptide / Proteins

u-Conotoxin GIIIB

SKU : BHP21300029

A Selective Blocker of Skeletal Muscle NaV1.4 Channels

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Mfr.No.	C-270, C-270_0.1 mg, C-270_0.25 mg, C-270_0.5 mg, C-270_1 mg, C-270_10 mg, C-270_5 mg, C-270_50 mcg
Description	A Selective Blocker of Skeletal Muscle NaV1.4 Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C101H175N39O30S7
Background	u-Conotoxin GIIIB was originally isolated from the marine snail Conus geographus. The peptide toxin selectively blocks NaV1.4 channels, which are expressed predominantly in skeletal muscle.1,2 It is a potent blocker and 600 nM completely blocked NaV1.4-related currents in rat skeletal muscle.3
Biological Activity	u-Conotoxin GIIIB binds and blocks site 1 of voltage-gated Na+ channels1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2640 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P01524
Concentration	100 - 600 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Cited Application: Electrophysiology Is Toxin: Yes
Cas Number	140678-12-2
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys3-Cys15, Cys4-Cys20, and Cys10-Cys21 X = 4-Hydroxyproline Ala22 - C-terminal amidation
Origin	Conus geographus (Geography cone) (Nubecula geographus)

Synonyms	Myotoxin II, Geographutoxin II, GTx-II
Gene Id	SCN4A
Sequence	RDCCTXXRKCKDRRCKXMKCCA-NH2
Target	NaV1.4 Na+ channels

Country Of Origin	Israel/IL
Purity	>=99% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Cruz, L.J. et al. (1985) J. Biol. Chem. 260, 9280. Li, R.A. et al. (2003) J. Biol. Chem. 278, 8717. Filatov, G.N. and Rich, M.M. (2004) J. Physiol. 559, 813. Robitaille, R. and Charlton, M.P. (1992) J. Neurosci. 12, 297. Cruz, L.J. et al. (1985) J. Biol. Chem. 260, 9280.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300029-1	C-270_0.1 mg	0.1 mg	$152		Add to Cart
BHP21300029-2	C-270_0.25 mg	0.25 mg	$303		Add to Cart
BHP21300029-3	C-270_0.5 mg	0.5 mg	$419		Add to Cart
BHP21300029-4	C-270_1 mg	1 mg	$670		Add to Cart
BHP21300029-5	C-270_10 mg	10 mg	$3725		Add to Cart
BHP21300029-6	C-270_5 mg	5 mg	$2342		Add to Cart
BHP21300029-7	C-270_50 mcg	50 mcg	$88		Add to Cart

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