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Home / Proteins & Peptide / Proteins

u-Conotoxin GIIIA

SKU : BHP21300159

A Blocker of NaV1.4 Na+ Channel

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Mfr.No.	STC-280, STC-280_0.1 mg, STC-280_0.5 mg, STC-280_1 mg, STC-280_10 mg, STC-280_5 mg
Description	A Blocker of NaV1.4 Na+ Channel
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C100H170N38O32S6
Background	u-Conotoxin GIIIA is a peptide toxin originally isolated from the venom of Conus geographus. It specifically blocks skeletal muscle Na+ channels (NaV1.4) with an IC50 of 1500 nM1.NaV channels are targets for many toxins, which bind with high affinity to various sites on the channel protein, u-Conotoxin selectively binds to the NaV1.4 channel, blocks the pore and disabling its normal function, act as an antagonist for VGSCs1.Voltage-gated NaV channels (VGSCs) play a key role in the electric excitability of cells by regulating the influx of sodium ions. VGSCs are responsible for initiating and propagating action potentials, which are essential for the activity of a wide selection of cells and tissues such as neurons, heart and muscle. In mammals, nine different subtypes (NaV1.1-1.9) have been identified, each with distinct distribution.VGSCs acts as a potential drug targets for related disorders such as cardiac and neuropathic diseases2,3.
Biological Activity	u-Conotoxin GIIIA is a NaV1.4 channel blocker1,2.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2609 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P01523
Concentration	50 - 500 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	129129-65-3
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys3-Cys15, Cys4-Cys20 and Cys10-Cys21 X = Hydroxyproline Ala22 - C-terminal amidation
Origin	Conus geographus (Geography cone) (Nubecula geographus)

Synonyms	G3.9, Geographutoxin I, GTx-I, Myotoxin I
Gene Id	SCN4A, SCN1A, SCN8A
Sequence	RDCCTXXKKCKDRQCKXQRCCA-NH2
Target	NaV1.4 Na+ channel

Country Of Origin	Israel/IL
Purity	>=99% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Mahdavi, S. and Kuyucak, S. (2014) PLoS ONE 9, 1371. Norton, R.S. (2010) Molecules 15, 2825. Cummins, T.R. et al. (2002) Mol. Pharmacol. 61, 1162. Sato, K. et al. (1991) J. Biol. Chem. 266, 16989. Olivera, B.M. et al. (1990) Science 249, 257.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300159-1	STC-280_0.1 mg	0.1 mg	$202		Add to Cart
BHP21300159-2	STC-280_0.5 mg	0.5 mg	$459		Add to Cart
BHP21300159-3	STC-280_1 mg	1 mg	$832		Add to Cart
BHP21300159-4	STC-280_10 mg	10 mg	$4489		Add to Cart
BHP21300159-5	STC-280_5 mg	5 mg	$2494		Add to Cart

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