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Home / Proteins & Peptide / Proteins

u-Conotoxin CnIIIC

SKU : BHP21300178

A Blocker of NaV Channels and an Antagonist of nAChRs

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Mfr.No.	STC-640, STC-640_0.1 mg, STC-640_0.5 mg, STC-640_1 mg, STC-640_50 mcg, STC-640_10 mg, STC-640_5 mg
Description	A Blocker of NaV Channels and an Antagonist of nAChRs
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C92H139N35O28S6
Background	u-Conotoxin CnIIIC, a 22-residue conopeptide from Conus consors belonging to u-conopeptide family, is a very potent, selective and durable antagonist of NaV channels. This toxin blocks both voltage-gated Na+ channels and neuronal nicotinic acetylcholine receptor (nAChR). u-Conotoxin CnIIIC inhibits the rat skeletal muscle NaV1.4 with IC50 of 1.3 nM and the rat brain NaV1.2 expressed in HEK-293 cells. A low inhibition is also observed for mouse neuronal NaV1.6 and mouse NaV1.7. u-Conotoxin CnIIIC modestly blocks nAChR alpha3/beta2 subtype with IC50 values of 450 nM (partially reversible) and, to a lesser extent, alpha7 and alpha4/beta2 subtypes (reversible) expressed in Xenopus oocytes. in vitro, it decreases twitch tension in mouse hemidiaphragms (IC50 = 150 nM) and displays a high blocking effect in mouse extensor digitorum longus muscles (IC50 = 46 nM).
Biological Activity	u-Conotoxin CnIIIC blocks NaV channels and alpha3/beta2 nAChRs.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2375.7 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	I1SB07
Concentration	0.5 - 1 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys3-Cys15, Cys4-Cys21 and Cys10-Cys22 Cys22 - C-terminal amidation Z - Pyrrolidone carboxylic acid (Glp)
Origin	Conus consors (Singed cone)

Synonyms	Mu-Conotoxin CnIIIC
Gene Id	CHRNA3,CHRNA4,CHRNA7 ,CHRNB2,SCN2A,SCN4A
Sequence	ZGCCNGPKGCSSKWCRDHARCC-NH2
Target	NaV channels, alpha3/beta2 nAChR

Country Of Origin	Israel/IL
Purity	>=99% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Favreau, P. et al. (2012) Br. J. Pharmacol. 166, 1654.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300178-1	STC-640_0.1 mg	0.1 mg	$185		Add to Cart
BHP21300178-2	STC-640_0.5 mg	0.5 mg	$483		Add to Cart
BHP21300178-3	STC-640_1 mg	1 mg	$577		Add to Cart
BHP21300178-4	STC-640_50 mcg	50 mcg	$152		Add to Cart
BHP21300178-5	STC-640_10 mg	10 mg	$2688		Add to Cart
BHP21300178-6	STC-640_5 mg	5 mg	$1920		Add to Cart

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