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Home / Proteins & Peptide / Proteins

u-Conotoxin BuIIIC

SKU : BHP21300185

A Blocker of NaV1.4 Channel

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Mfr.No.	STC-690, STC-690_0.1 mg, STC-690_0.5 mg, STC-690_50 mcg, STC-690_1 mg, STC-690_10 mg, STC-690_5 mg
Description	A Blocker of NaV1.4 Channel
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C116H189N49O34S6
Background	u-conotoxin BuIIIC, is a peptide toxin originally isolated from Conus Bullatus (Bubble cone). It has the characteristic arrangement of six-cysteine residues (-CC-C-C-CC-) and comprises 26 amino acid residues. u-conotoxin BuIIIC was demonstrated to be a potent irreversible inhibitor of the voltage-gated Na+ channel skeletal muscle subtype NaV1.4, expressed in Xenopus oocytes. 1 uM toxin was shown to block 96% of the channel. The novel structural determinants of BuIIIC along with its ability to potently inhibit NaV1.4 make this conotoxin useful in defining features of the NaV1.4 pharmacophore and thereby facilitate the design of highly subtype-specific ligands that target NaV1.41.
Biological Activity	u-Conotoxin BuIIIC is a selective NaV1.4 blocker1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	3006 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	C1J5M7
Concentration	1 pM - 20 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys5-Cys19, Cys6-Cys25, and Cys15-Cys26 Cys26 - C-terminal amidation
Origin	Conus bullatus (Bubble cone)

Synonyms	Mu-Conotoxin BuIIIC
Gene Id	SCN4A
Sequence	IVDRCCNKGNGKRGCSRWCRDHSRCC-NH2
Target	NaV1.4 Na+ channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Holford, M. et al. (2009) Toxicon 53, 90. Holford, M. et al. (2009) Toxicon 53, 90.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300185-1	STC-690_0.1 mg	0.1 mg	$266		Add to Cart
BHP21300185-2	STC-690_0.5 mg	0.5 mg	$1684		Add to Cart
BHP21300185-3	STC-690_50 mcg	50 mcg	$170		Add to Cart
BHP21300185-4	STC-690_1 mg	1 mg	$824		Add to Cart
BHP21300185-5	STC-690_10 mg	10 mg	$3531		Add to Cart
BHP21300185-6	STC-690_5 mg	5 mg	$2880		Add to Cart

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