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Home / Proteins & Peptide / Proteins

u-Conotoxin BuIIIB

SKU : BHP21300182

A Blocker of NaV1.4 and NaV1.3 and NaV1.2 Na+ Channels

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Mfr.No.	STC-661, STC-661_0.1 mg, STC-661_50 mcg
Description	A Blocker of NaV1.4 and NaV1.3 and NaV1.2 Na+ Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C106H172N46O30S6
Background	u-Conotoxin BuIIIB, is a peptide toxin originally isolated from Conus Bullatus (Bubble cone). It is characterized by a six-cysteine frame-work (-CC-C-C-CC-) cross-linked by three disulfide bridges. u-Conotoxin BuIIIB was demonstrated to be a potent irreversible inhibitor of the NaV skeletal muscle subtype NaV1.4 heterologously expressed in Xenopus oocytes. 1 uM toxin was shown to block 96% of the channel1. In addition, u-conotoxin BuIIIB potently blocks NaV1.3 expressed in oocytes, with an IC50 of 0.1 uM NaV1.3 is involved in pain perception; therefore u-conotoxin BuIIIB should serve as a valuable tool to evaluate the contribution of the NaV1.3 subtype to various pain states2,3.
Biological Activity	u-Conotoxin BuIIIB is a selective NaV1.2, NaV1.3 and NaV1.4 blocker1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2763 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	C1J5M6
Concentration	1 - 20 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys5-Cys17, Cys6-Cys23, and Cys13-Cys24 Cys24 - C-terminal amidation
Origin	Conus bullatus (Bubble cone)

Synonyms	Mu-Conotoxin BuIIIB
Gene Id	SCN1A,SCN2A,SCN3A,SCN4A
Sequence	VGERCCKNGKRGCGRWCRDHSRCC-NH2
Target	NaV1.2, NaV1.3 and NaV1.4 Na+ channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Holford, M. et al. (2009) Toxicon 53, 90. Norton, R.S. (2010) Molecules 15, 2825. Wilson, M.J. et al.(2011) Proc. Natl. Acad. Sci. U.S.A. 108, 10302. Wilson, M.J. et al.(2011) Proc. Natl. Acad. Sci. U.S.A. 108, 10302.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300182-1	STC-661_0.1 mg	0.1 mg	$575		Add to Cart
BHP21300182-2	STC-661_50 mcg	50 mcg	$325		Add to Cart

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