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Home / Proteins & Peptide / Proteins

u-Conotoxin BuIIIA

SKU : BHP21300174

A Selective and Potent Blocker of NaV1.2 and NaV1.4 Channels

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Mfr.No.	STC-540, STC-540_0.1 mg, STC-540_0.5 mg, STC-540_1 mg, STC-540_50 mcg
Description	A Selective and Potent Blocker of NaV1.2 and NaV1.4 Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C106H172N44O31S6
Background	u-Conotoxins (u-CTX) are peptide toxins that block voltage-gated Na+ channels (VGSCs), which are responsible for the influx of Na+ ions during action potentials in excitable tissues1.u-Conotoxin BuIIIA is originally isolated from the venom of the cone snail Conus bullatus and acts as a selective and potent blocker of voltage-gated NaV1.2 and NaV1.4 channels. The conotoxin inhibits Na+ flux by blocking the Na+ channel pore.BuIIIA is considered to be part of a novel class of u-conopeptides discovered from a newly defined class of fish-hunting cone snails, the Textilia clade. In addition, Conus bullatus peptides help define a new branch of the M-superfamily of conotoxins, namely M-5 due to a unique N-terminal extension. This N-terminus also exists in u-Conotoxin BuIIIB and BuIIIC but absent in all other u-conotoxins2,3.u-Conotoxin BuIIIA is used to determine the structure-activity relationship of voltage-gated Na+ channels3.
Biological Activity	u-Conotoxin BuIIIA is a potent blocker of voltage-gated NaV1.2 and NaV1.4 channels.1
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2751 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	C1J5M5
Concentration	100 nM - 1 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys5-Cys16, Cys6-Cys22, and Cys12-Cys23 Cys23 - C-terminal amidation
Origin	Conus bullatus (Bubble cone)

Synonyms	Mu-conotoxin BuIIIA
Gene Id	SCN2A,SCN4A
Sequence	VTDRCCKGKRECGRWCRDHSRCC-NH2
Target	NaV1.2, NaV1.4 channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Yao, S. et al. (2008) Biochemistry 47, 10940. Kuang, Z. et al. (2013) ACS Chem. Biol. 8, 1344. Holford, M. et al. (2009) Toxicon 53, 90. Holford, M. et al. (2009) Toxicon 53, 90.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300174-1	STC-540_0.1 mg	0.1 mg	$325		Add to Cart
BHP21300174-2	STC-540_0.5 mg	0.5 mg	$1287		Add to Cart
BHP21300174-3	STC-540_1 mg	1 mg	$1805		Add to Cart
BHP21300174-4	STC-540_50 mcg	50 mcg	$193		Add to Cart

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