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Home / Proteins & Peptide / Proteins

Tertiapin-Q

SKU : BHP21300291

A Potent Blocker of Inward Rectifier (Kir) K+ Channels

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Mfr.No.	STT-170, STT-170_0.1 mg, STT-170_0.25 mg, STT-170_0.5 mg, STT-170_1 mg, STT-170_10 mg, STT-170_5 mg
Description	A Potent Blocker of Inward Rectifier (Kir) K+ Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C106H175N35O24S4
Background	Tertiapin, the native toxin, was originally isolated from European honey bee Apis mellifera venoM Native and synthetic Tertiapin blocks a range of inward rectifier K+ channels (Kir), in particular ROMK1 (Kir1.1, IC50 = 2 nM) and GIRK (Kir3 family, IC50 for the Kir3.1/3.4 heteromer was 8.6 nM) but with no effect on the Kir2 family member1. In accordance, it was shown to inhibit acetylcholine induced K+ currents in mammalian cardiomyocytes2,3.Tertiapin-Q is a derivative of Tertiapin in which Met13 is substituted by a Gln residue. However, unlike native Tertiapin, Tertiapin-Q is non-oxidizable and therefore is more stable4.Tertiapin-Q inhibits the above-mentioned channels with similar affinities and also inhibits Ca2-activated large conductance BK-type K+ channels in a concentration and voltage-dependent manner5.
Biological Activity	Tertiapin-Q blocks a range of inward rectifier K+ channels (Kir), in particular ROMK1 and GIRK, but with no effect on Kir2 family members1. In addition, it was shown to inhibit acetylcholine induced K+ currents in heart2,3. Tertiapin-Q is a derivative of Tertiapin in which Met13 is replaced by Gln. Tertiapin-Q inhibits the above-mentioned channels with similar affinities4.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2452 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P56587
Concentration	2 - 200 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Cited Application: Electrophysiology Is Toxin: Yes
Cas Number	910044-56-3
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys3-Cys14, Cys5-Cys18 Lys21 - C-terminal amidation ATTO Fluor-488
Origin	Apis mellifera (Honeybee)

Synonyms	TPN-Q
Gene Id	KCNJ1,KCNJ3,KCNJ5,KCNJ6, KCNMA1
Sequence	ALCNCNRIIIPHQCWKKCGKK-NH2
Target	Kir1.1, Kir3.2 K+ channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Jin, W. and Lu, Z. (1998) Biochemistry 37, 13291. Drici, M.D. et al. (2000) Br. J. Pharmacol. 131, 569. Kitamura, H. et al. (2000) J. Pharmacol. Exp. Ther. 293, 196. Peleg, S. et al. (2002) Neuron 33, 87. Kanjhan, R. et al. (2005) J. Pharmacol. Exp. Ther. 314, 1353. Jin, W. and Lu, Z. (1998) Biochemistry 37, 13291. Drici, M.D. et al. (2000) Br. J. Pharmacol. 131, 569. Kitamura, H. et al. (2000) J. Pharmacol. Exp. Ther. 293, 196. Jin, W. et al. (1999) Biochemistry 38, 14294.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300291-1	STT-170_0.1 mg	0.1 mg	$110		Add to Cart
BHP21300291-2	STT-170_0.25 mg	0.25 mg	$218		Add to Cart
BHP21300291-3	STT-170_0.5 mg	0.5 mg	$295		Add to Cart
BHP21300291-4	STT-170_1 mg	1 mg	$471		Add to Cart
BHP21300291-5	STT-170_10 mg	10 mg	$3012		Add to Cart
BHP21300291-6	STT-170_5 mg	5 mg	$1882		Add to Cart

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