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Home / Proteins & Peptide / Proteins

Tertiapin-Q-ATTO Fluor-633

SKU : BHP21300293

An Inward Rectifier K+ Channel Blocker Conjugated to the Fluorescent Dye ATTO-633

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Mfr.No.	STT-170-FR, STT-170-FR_5 mcg
Description	An Inward Rectifier K+ Channel Blocker Conjugated to the Fluorescent Dye ATTO-633
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is lyophilized in 0.5 ml conical vial. The product is soluble in pure water to high-micromolar concentrations (5 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity. Avoid exposure to light.
Background	Tertiapin, the native toxin, was originally isolated from European honey bee Apis mellifera venoM Native and synthetic Tertiapin blocks a range of inward rectifier K+ channels (Kir), in particular ROMK1 (Kir1.1, IC50 = 2 nM) and GIRK (Kir3 family, IC50 for the Kir3.1/3.4 heteromer was 8.6 nM) but with no effect on the Kir2 family member1. In accordance, it was shown to inhibit acetylcholine induced K+ currents in mammalian cardiomyocytes2,3.Tertiapin-Q is a derivative of Tertiapin in which Met13 is substituted by a Gln residue. However, unlike native Tertiapin, Tertiapin-Q is non-oxidizable and therefore is more stable4.Tertiapin-Q inhibits the above-mentioned channels with similar affinities and also inhibits Ca2-activated large conductance BK-type K+ channels in a concentration and voltage-dependent manner5.
Biological Activity	Tertiapin-Q blocks a range of inward rectifier K+ channels (Kir), in particular ROMK1 and GIRK, but with no effect on Kir2 family members1,2. In addition, it was shown to inhibit acetylcholine induced K+ currents in the heart3,4.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	3159.6 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is lyophilized in 0.5 ml conical vial. The product is soluble in pure water to high-micromolar concentrations (5 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity. Avoid exposure to light.
Source	Modified synthetic peptide
Concentration	50 - 200 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys³-Cys¹⁴, Cys⁵-Cys¹⁸ Lys²¹- C-terminal amidation ATTO Fluor-633
Origin	Apis mellifera (Honeybee)

Gene Id	KCNJ1,KCNJ3,KCNJ5, KCNJ6, KCNMA1
Sequence	ALCNCNRIIIPHQCWKKCGKK-NH2
Target	K_ir1.1, K_ir3.2 K⁺channels

Country Of Origin	Israel/IL
Storage	Storage After Reconstitution: Store the reconstituted solution at -20°C for the shortest time possible. Avoid multiple freeze-thaw cycles. We do not recommend storing the product in working solutions for longer than a day. Avoid exposure to light. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Store the reconstituted solution at -20°C for the shortest time possible. Avoid multiple freeze-thaw cycles. We do not recommend storing the product in working solutions for longer than a day. Avoid exposure to light.

Applications	Electrophysiology, Live cell imaging, Immunofluorescence, Fluorescence staining, Direct flow cytometry

Reference	Jin, W. and Lu, Z. (1998) Biochemistry 37, 13291. Drici, M.D. et al. (2000) Br. J. Pharmacol. 131, 569. Kitamura, H. et al. (2000) J. Pharmacol. Exp. Ther. 293, 196. Peleg, S. et al. (2002) Neuron 33, 87. Kanjhan, R. et al. (2005) J. Pharmacol. Exp. Ther. 314, 1353. Jin, W. and Lu, Z. (1998) Biochemistry 37, 13291. Jin, W. et al. (1999) Biochemistry 38, 14294. Drici, M.D. et al. (2000) Br. J. Pharmacol. 131, 569. Kitamura, H. et al. (2000) Pharmacol. Exp. Ther. 293, 196.

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300293-1	STT-170-FR_5 mcg	5 mcg	$891		Add to Cart
BHP21300293-2	STT-170-FR_5 mcg	5x5 mcg	$3561		Add to Cart

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