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Home / Proteins & Peptide / Proteins

Taipoxin

SKU : BHP21300313

A Blocker of Synaptic Vesicle Recycling

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Mfr.No.	T-460, T-460_0.5 mg
Description	A Blocker of Synaptic Vesicle Recycling
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Background	Taipoxin is a lethal neurotoxin protein isolated from the venom of the Australian taipan Oxyuranus s. scutellatus (LD50= 2 ug/kg in mouse). Taipoxin is a non-covalent ternary glycoprotein which is completely dissociated at low pH or high ionic strength. One of the subunits has Phospholipase A2 activity1,2.Intoxicated animals die of asphyxia caused by a complete inhibition of neurotransmitter release and neuromuscular junction blockage of the respiratory muscles. In the central nervous system taipoxin blocks synaptic vesicle recycling by inhibiting the neuronal uptake pathway through the interaction with neuronal Pentraxin system components during synapse formation and remodeling1,3-5.In neuronal cultures, Taipoxin facilitates Ca2+-dependent synaptic vesicle exocytosis and causes a complete depletion of stored neurotransmitter, resulting in synaptic transmission blockage. Taipoxin, at nanomolar range, causes swelling of nerve terminus and redistribution of synaptic vesicle proteins7.
Biological Activity	Taipoxin gradually and completely stops induced and spontaneous release of acetylcholine from nerve terminals1. Taipoxin is considered to be the most potent toxin.
Formulation	Lyophilized from filtrated Ammonium acetate solution. May contain acetate as a residual counter ion.
Molecular Weight	46 kDa
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Natural protein
Concentration	10 - 50 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	52019-39-3
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Highly disulfide bridged protein, glycosylated
Origin	Oxyuranus scutellatus scutellatus (Australian taipan) (Coastal taipan)

Synonyms	Taipan toxin
Gene Id	NPTX1,NPTX2,NPTXR
Sequence	Î±, Î² and Î³ chains non-covalently linkedS

Country Of Origin	Israel/IL
Purity	>=97% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Immunocytochemistry, Neurite outgrowth assay

Reference	Fohlman, J. et al. (1976) Eur. J. Biochem 68, 457. Lind, P. and Eaker, D. (1982) Eur. J. Biochem. 124, 441. Cull-Candy, S. et al. (1976) Neuroscience 1, 175. Kirkpatrick, L.L. et al. (2000) J. Biol. Chem. 275, 17786. Lambeau, G. et al. (1989) J. Biol. Chem. 264, 11503. Bonanomi, D. et al. (2005) Mol. Pharmacol. 67, 1901. Dreyer, F. and Penner, R. (1987) J. Physiol. 386, 455. Fohlman, J. et al. (1976) Eur. J. Biochem. 68, 457.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300313-1	T-460_0.5 mg	0.5 mg	$354		Add to Cart
BHP21300313-2	T-460_0.5 mg	5x0.5 mg	$1403		Add to Cart

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