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Home / Proteins & Peptide / Proteins

Stichodactyla Toxin-ATTO Fluor-590

SKU : BHP21300281

Fluorescent ShK Conjugate for Sensitive Detection of KV Channels

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Mfr.No.	STS-400-AR, STS-400-AR_5 mcg
Description	Fluorescent ShK Conjugate for Sensitive Detection of KV Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is lyophilized in 0.5 ml conical vial. The product is soluble in pure water to high-micromolar concentrations (5 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity. Avoid exposure to light.
Background	ShK (Stichodactyla Toxin) is a peptide toxin originally isolated from the nematocyst of the sea anemone Stichodactyla helianthus1.ShK blocks KV1.3, KV1.1, KV1.4, and KV1.6 at subnanomolar concentrations and KV3.2 channels at 1000-fold higher concentration than that required to inhibit KV1.3 channels. It has been shown to block KV current in DRG neurons, to displace radioactive Dendrotoxin from brain synaptosomes1 and inhibit I125-Charybdotoxin binding to Jurkat T lymphocytes with an IC50 of 32 pM2,4.Evidence also suggests that native KV currents in the central nervous system, which are predominantly carried by KV1.2 channels, are highly sensitive to this toxin5.A fluorescently labeled synthetic ShK is used to recognize and to sort KV1.3 containing lymphocytes4,6.
Biological Activity	Stichodactyla Toxin blocks KV1.3, KV1.1, KV1.4, and KV1.6 at subnanomolar concentrations and KV3.2 channels at 1000-fold higher concentration than that required to inhibit KV1.3 channels1-3.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	~4627 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is lyophilized in 0.5 ml conical vial. The product is soluble in pure water to high-micromolar concentrations (5 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity. Avoid exposure to light.
Source	Modified synthetic peptide
Concentration	1 - 100 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys3-Cys35, Cys12-Cys28, Cys17-Cys32 ATTO Fluor-590
Origin	Stichodactyla helianthus (Sun anemone) (Stoichactis helianthus)

Synonyms	K+ channel toxin ShK, Toxin kappa-stichotoxin-She3a, Kappa-stichotoxin-She3a, kappa-SHTX-She3a
Gene Id	KCNA1 ,KCNA2 ,KCNA3,KCNA4,KCNA6,KCNA7,KCNN4
Sequence	RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC-OH
Target	KV1.1, KV1.3, KV1.4, KV1.6 channels

Country Of Origin	Israel/IL
Storage	Storage After Reconstitution: Store the reconstituted solution at -20°C for the shortest time possible. Avoid multiple freeze-thaw cycles. We do not recommend storing the product in working solutions for longer than a day. Avoid exposure to light. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Store the reconstituted solution at -20°C for the shortest time possible. Avoid multiple freeze-thaw cycles. We do not recommend storing the product in working solutions for longer than a day. Avoid exposure to light.

Applications	Electrophysiology, Live cell imaging, Immunofluorescence, Direct flow cytometry

Reference	Castaneda, O. et al. (1995) Toxicon 33, 603. Pennington, M.W. et al. (1995) Int. J. Pept. Protein Res. 46, 354. Beeton, C. et al. (2003) J. Biol. Chem. 278, 9928. Middleton, R.E. et al. (2003) Biochemistry 42, 13698. Yan, L. et al. (2005) Mol. Pharmacol. 67, 1513. Pennington, M.W. et al. (1995) Int. J. Pept. Protein Res. 46, 354. Beeton, C. et al. (2003) J. Biol. Chem. 278, 9928. Middleton, R.E. et al. (2003) Biochemistry 42, 13698.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300281-1	STS-400-AR_5 mcg	5 mcg	$642		Add to Cart
BHP21300281-2	STS-400-AR_5 mcg	5x5 mcg	$2238		Add to Cart
BHP21300281-3	STS-400-AR_5 mcg	10x5 mcg	$3062		Add to Cart

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