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Home / Proteins & Peptide / Proteins

Spinoxin

SKU : BHP21300284

A Potent Blocker of KV1.2 and KV1.3 Channels

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Mfr.No.	STS-500, STS-500_0.1 mg, STS-500_0.5 mg, STS-500_1 mg, STS-500_5 mg, STS-500_50 mcg
Description	A Potent Blocker of KV1.2 and KV1.3 Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C147H236N48O46S9
Background	Spinoxin (SPX, alpha-KTx6.13) is a 34-residue peptide toxin originally isolated from the scorpion Heterometrus spinifer venoM Spinoxin is a potent KV1.3 channel blocker displaying IC50 values of 63 nM It also has high affinity towards KV1.2 channels1,2.K+ ion channels play an important role in the modulation of Ca2+ signaling by controlling the membrane potential. These channels are considered to be very important targets in the diagnostics and therapy in several autoimmune disorders and cancers1.
Biological Activity	Spinoxin is a potent blocker of KV1.2 and KV1.3 channels1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	3700.4 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P84094
Concentration	2 - 100 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	752984-66-0
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys3-Cys24, Cys9-Cys29, Cys13-Cys31 and Cys19-Cys34 Cys34 - C-terminal amidation
Origin	Heterometrus spinifer (Asia giant forest scorpion) (Malaysian black scorpion)

Synonyms	Potassium channel toxin alpha-KTx 6.13, SPX, alpha-KTx6.13
Gene Id	KCNA2 ,KCNA3
Sequence	IRCSGSRDCYSPCMKQTGCPNAKCINKSCKCYGC-NH2
Target	KV1.2, KV1.3 channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Peigneur, S. et al. (2016) Biochemistry. 55, 2927. Yamaguchi, Y. et al. (2016) Toxicon 122, 31. Peigneur, S. et al. (2016) Biochemistry. 55, 2927.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300284-1	STS-500_0.1 mg	0.1 mg	$235		Add to Cart
BHP21300284-2	STS-500_0.5 mg	0.5 mg	$705		Add to Cart
BHP21300284-3	STS-500_1 mg	1 mg	$1152		Add to Cart
BHP21300284-4	STS-500_5 mg	5 mg	$3360		Add to Cart
BHP21300284-5	STS-500_50 mcg	50 mcg	$168		Add to Cart

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