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Home / Proteins & Peptide / Proteins

Slotoxin

SKU : BHP21300283

A Blocker of KCa1.1 Channel

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Mfr.No.	STS-410, STS-410_0.1 mg, STS-410_0.5 mg, STS-410_1 mg, STS-410_10 mg, STS-410_5 mg
Description	A Blocker of KCa1.1 Channel
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C177H275N47O50S7
Background	Native Slotoxin was originally isolated from Centruroides noxius scorpion venoMNative Slotoxin blocks the Maxi K+ (BKCa or slo, KCNMA1, KCa1.1) channels.1Slotoxin blocks differentially channels formed by the alpha1 subunit alone and channels formed by the alpha1 combined with auxiliary beta subunits. In Xenopus oocytes expressing hSlo (alpha1 alone), Kd was calculated to be 1.5 nM and the block is complete and reversible. With the additional co-expression of either the beta1 or beta4 subunits, the block become irreversible or causes the channel to be almost insensitive to the toxin, respectively.1
Biological Activity	Slotoxin inhibits the Maxi K+ (BKCa or mSlo, KCNMA1, KCa1.1) channels1. Slotoxin differentially blocks channels formed by the alpha1 subunit alone and channels formed by the alpha1 combined with auxiliary beta subunits.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	4085.9 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P0C182
Concentration	10 - 100 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	401470-29-9
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35
Origin	Centruroides noxius (Mexican scorpion)

Synonyms	K+ channel toxin alpha-KTx 1.11, SloTx
Gene Id	KCNMA1
Sequence	TFIDVDCTVSKECWAPCKAAFGVDRGKCMGKKCKCYV-OH
Target	KCa1.1 K+ channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Garcia-Valdes, J. et al. (1998) FEBS. Lett. 505, 369. Garcia-Valdes, J. et al. (1998) FEBS. Lett. 505, 369.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300283-1	STS-410_0.1 mg	0.1 mg	$249		Add to Cart
BHP21300283-2	STS-410_0.5 mg	0.5 mg	$768		Add to Cart
BHP21300283-3	STS-410_1 mg	1 mg	$1036		Add to Cart
BHP21300283-4	STS-410_10 mg	10 mg	$5074		Add to Cart
BHP21300283-5	STS-410_5 mg	5 mg	$3615		Add to Cart

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