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Home / Proteins & Peptide / Proteins

ProTx-III

SKU : BHP21300264

A Potent Blocker of NaV1.7 Channels

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Mfr.No.	STP-150, STP-150_0.1 mg, STP-150_0.25 mg, STP-150_0.5 mg, STP-150_1 mg, STP-150_10 mg, STP-150_5 mg, STP-150_50 mcg
Description	A Potent Blocker of NaV1.7 Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C162H246N52O43S6
Background	ProTx-III (u-TRTX-Tp1a) originally isolated from the venom of the peruvian green-velvet tarantula Thrixopelma pruries, is a potent blocker of voltage-gated sodium (NaV) channels, with highest affinity towards NaV1.7 with an IC50 of 11.5 nM, and demonstrates analgesic properties in in vivo models1.NaV channels are responsible for initiating action potentials in electrically excitable cells. They play an important role in the human pain signalling pathway and are important therapeutic targets for treatment of chronic pain. Mutations in NaV channels are also associated with a range of complex pathologic conditions such as epilepsy, myotonic conditions and cardiac arrhythmias1,2.
Biological Activity	ProTx-III is a potent blocker of NaV1.7 voltage-gated Na+ channels1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	3802.5 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P0DL64
Concentration	1 - 250 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys2-Cys17, Cys9-Cys22, and Cys16-Cys29 Ile 33 - C-terminal amidation
Origin	Thrixopelma pruriens (Peruvian green velvet tarantula)

Synonyms	u-theraphotoxin-Tp1a, u-TRTX-Tp1a, Protoxin III, ProTx III
Gene Id	SCN1A,SCN2A,SCN3A,SCN8A,SCN9A
Sequence	DCLKFGWKCNPRNDKCCSGLKCGSNHNWCKLHI-NH2
Target	NaV1.7 channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Cardoso, F.C. et al. (2015) Mol. Pharmacol. 88, 291. Namadurai, S. et al. (2015) Open Biol. 5, 140192. Cardoso, F.C. et al. (2015) Mol. Pharmacol. 88, 291.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300264-1	STP-150_0.1 mg	0.1 mg	$198		Add to Cart
BHP21300264-2	STP-150_0.25 mg	0.25 mg	$396		Add to Cart
BHP21300264-3	STP-150_0.5 mg	0.5 mg	$633		Add to Cart
BHP21300264-4	STP-150_1 mg	1 mg	$1012		Add to Cart
BHP21300264-5	STP-150_10 mg	10 mg	$6467		Add to Cart
BHP21300264-6	STP-150_5 mg	5 mg	$4042		Add to Cart
BHP21300264-7	STP-150_50 mcg	50 mcg	$119		Add to Cart

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