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Home / Proteins & Peptide / Proteins

PLTX-II

SKU : BHP21300096

An Inhibitor of CaV Channels

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Mfr.No.	P-510, P-510_5 mcg
Description	An Inhibitor of CaV Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C208H313N61O70S10
Background	Plectreurys toxin (PLTX-II) is a 44 amino acid peptidyl toxin produced by Plectreurys tristis spider1,2. PLTXII was found as a potent blocker of the CaV2 channel (CAC) that inactivates Ca2+ currents in pupal neurons3 and in antennal lobe PNs of adult Drosophila brain. PLTX-II regulates the miniature excitatory postsynaptic current frequency at excitatory cholinergic synapses of these neurons in vitro and in situ and acts as a presynaptic Ca2+-channel blocker3,4.
Biological Activity	PLTX-II is a voltage-gated Ca2+ channel blocker.
Formulation	Lyophilized Powder.
Molecular Weight	5108.7 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Natural peptide
Accession Number	P34079
Concentration	10 - 50 nM
Form	Lyophilized
Notes	Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys3-Cys17, Cys10-Cys23, Cys16-Cys35, Cys20-Cys42 and Cys25-Cys33 Thr44 - C-terminal amidation and Opalmitoylation
Origin	Plectreurys tristis (Spider) (Plectreurys bispinosus)

Synonyms	omega-Plectoxin-Pt1a, omega-PLTX-Pt1a, PLTX-2
Gene Id	CACNA, CACNA1B, CACNA1E
Sequence	ADCSATGDTCDHTKKCCDDCYTCRCGTPWGANCRCDYYKARCDT-NH2
Target	CaV Ca2+ channels

Country Of Origin	Israel/IL
Purity	>=99% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Reference	Leung, H.T. et al. (1989) Neuron 3, 767. Branton, W.D. et al. (1993) Nature 365, 496. Gu, H. et al. (2009) J. Neurophysiol. 101, 42. Hou, J. et al. (2008) J. Neurophysiol. 100, 2833.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300096-1	P-510_5 mcg	5 mcg	$485		Add to Cart
BHP21300096-2	P-510_5 mcg	5x5 mcg	$1925		Add to Cart

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