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Home / Proteins & Peptide / Proteins

omega-Grammotoxin SIA

SKU : BHP21300211

A Blocker of CaV2.1 (P-type) and CaV2.2 (N-type) Channels

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Mfr.No.	STG-450, STG-450_0.1 mg, STG-450_0.5 mg, STG-450_1 mg, STG-450_5 mg, STG-450_50 mcg
Description	A Blocker of CaV2.1 (P-type) and CaV2.2 (N-type) Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C177H263N53O49S6
Background	omega-Grammotoxin SIA is a 36 amino acid peptidyl toxin originally isolated from the venom of the South American Tarantula spider, Grammostola spatulata. omega-Grammotoxin SIA potently inhibits both CaV2.1 (P-type) and CaV2.2 (N-type) Ca2+ channels by altering the voltage-dependence of channel gating. omega-Grammotoxin SIA caused a concentration-dependent and virtually complete inhibition of K+-evoked influx of 45Ca2+ into either rat or chick brain synaptosomes.1 omega-Grammotoxin SIA at 1 uM, a maximally effective concentration, blocked 52% of IBa in cultured rat hippocampal neurons.2 A concentration of >50 nM toxin completely inhibited Ca2+ currents in Purkinje neurons (predominantly, P-type channels) and in sympathetic neurons (predominantly, N-type channels).3
Biological Activity	omega-Grammotoxin SIA is a potent inhibitor of both P- and N-type Ca2+ channels1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	4109.8 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P605090
Concentration	50 - 500 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	152617-90-8
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between Cys2-Cys16, Cys9-Cys21, and Cys15-Cys30V36 - C-terminal amidation
Origin	Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata)

Synonyms	Omega-theraphotoxin-Gr1a, omega-TRTX-Gr1a, omega-GrTx SIA, omega-GsTx SIA, Omega-GTX SIA
Gene Id	CACNA1A, CACNA1B
Sequence	DCVRFWGKCSQTSDCCPHLACKSKWPRNICVWDGSV-NH2
Target	P-type and N-type Ca2+ channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Lampe R.A. et al. (1993) Mol. Pharmacol. 44, 451. Piser T.M. et al. (1995) Mol. Pharmacol. 48, 131. McDonough, S.I. et al. (1997) Mol. Pharmacol. 52, 1095. Lampe R.A. et al. (1993) Mol. Pharmacol. 44, 451.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300211-1	STG-450_0.1 mg	0.1 mg	$185		Add to Cart
BHP21300211-2	STG-450_0.5 mg	0.5 mg	$634		Add to Cart
BHP21300211-3	STG-450_1 mg	1 mg	$1012		Add to Cart
BHP21300211-4	STG-450_5 mg	5 mg	$3542		Add to Cart
BHP21300211-5	STG-450_50 mcg	50 mcg	$152		Add to Cart

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