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Home / Proteins & Peptide / Proteins

omega-Conotoxin SVIB

SKU : BHP21300151

A Potent Blocker of N-Type CaV Channels

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Mfr.No.	STC-160, STC-160_0.1 mg, STC-160_0.5 mg, STC-160_1 mg, STC-160_50 mcg
Description	A Potent Blocker of N-Type CaV Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C105H176N38O36S6
Background	omega-Conotoxin SVIB, an analogue of omega-conotoxin GVIA, is a peptide toxin originally isolated from Conus striatus venoM It is a potent blocker of N-type voltage-gated Ca2+ channels. It has an analgesic effect and is being used as a potential drug for the treatment of chronic and neuropathic pain models1,2.omega-Conotoxins are disulfide-rich peptides comprises 24-31 amino acids, isolated from the venom of marine predatory cone snails. These conotoxins have a high content of basic amino acid residue and a common cysteine scaffold that stabilizes the four-loop framework2,3.Voltage-gated N-Type Ca2+ channels are predominantly expressed in nerve terminals and are involved in the regulation of neuronal excitability and nociceptive signals. These channels play an important role in the transduction of acute and chronic pain perception. They are able to transduce electrical activity into other cellular functions and regulate calcium homeostasis3.
Biological Activity	omega-Conotoxin SVIB is a potent blocker of voltage-gated Ca2+ channels1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2739 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P28881
Concentration	10 - 50 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys1-Cys16, Cys8-Cys20, and Cys15-Cys26 Cys26 - C-terminal amidation
Origin	Conus striatus (Striated cone)

Synonyms	SNX-183
Gene Id	CACNA1B, CACNA1A
Sequence	CKLKGQSCRKTSYDCCSGSCGRSGKC-NH2
Target	N-Type CaV channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Ramilo, C.A. et al. (1992) Biochemistry 31, 9919. Lee, S. et al. (2010) Mol. Pain 6, 97. Adams, D.J. and Berecki, G. (2013) Biochim. Biophys. Acta. 1828, 1619. Ramilo, C.A. et al. (1992) Biochemistry 31, 9919.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300151-1	STC-160_0.1 mg	0.1 mg	$235		Add to Cart
BHP21300151-2	STC-160_0.5 mg	0.5 mg	$459		Add to Cart
BHP21300151-3	STC-160_1 mg	1 mg	$808		Add to Cart
BHP21300151-4	STC-160_50 mcg	50 mcg	$170		Add to Cart

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