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Home / Proteins & Peptide / Proteins

omega-Conotoxin SO3

SKU : BHP21300169

A Blocker of N-Type Ca2+ Channels

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Mfr.No.	STC-470, STC-470_0.1 mg, STC-470_0.25 mg, STC-470_0.5 mg, STC-470_1 mg, STC-470_10 mg, STC-470_5 mg
Description	A Blocker of N-Type Ca2+ Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C100H166N36O31S6
Background	omega-conotoxin SO-3 is a peptide toxin originally isolated from the venom of Conus striatus. It is a selective blocker of N-type CaV channels. SO-3 inhibits INa and IK with IC50 values of 0.49 and 1.6 mM respectively. omega-conotoxin SO-3 does not show any inhibiting effects on L-type, P/Q-type and R-type currents at 3 uM concentration and has no effect on NaV currents, delayed rectifier K+ currents and transient outward K+ currents. omega-conotoxin SO-3 displays an analgesic potency similar to omega-conotoxin MVIIA in a range of acute and chronic pain models in rodents, but has less adverse effects compared with identical dosages of omega-conotoxin MVIIA injected intrathecally1.
Biological Activity	omega-Conotoxin SO3 is a selective N-type Ca2+ channel inhibitor1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2561 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	Q9XZK2
Concentration	20 - 500 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	441284-32-8
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys1-Cys16, Cys8-Cys20, and Cys15-Cys25 Cys25 - C-terminal amidation
Origin	Conus striatus (Striated cone)

Synonyms	SO3
Gene Id	CACNA1B
Sequence	CKAAGKPCSRIAYNCCTGSCRSGKC-NH2
Target	CaV2.2 Ca2+ channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Li, Z. et al. (2003) Brain Res. 7, 155. Wen, L. et al. (2005) Br. J. Pharmacol. 145, 728.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300169-1	STC-470_0.1 mg	0.1 mg	$218		Add to Cart
BHP21300169-2	STC-470_0.25 mg	0.25 mg	$483		Add to Cart
BHP21300169-3	STC-470_0.5 mg	0.5 mg	$769		Add to Cart
BHP21300169-4	STC-470_1 mg	1 mg	$1232		Add to Cart
BHP21300169-5	STC-470_10 mg	10 mg	$6028		Add to Cart
BHP21300169-6	STC-470_5 mg	5 mg	$4307		Add to Cart

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