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Home / Proteins & Peptide / Proteins

omega-Conotoxin RVIA

SKU : BHP21300194

A Blocker of CaV2.2 Ca2+ Channel

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Mfr.No.	STC-850, STC-850_0.1 mg, STC-850_0.25 mg, STC-850_0.5 mg
Description	A Blocker of CaV2.2 Ca2+ Channel
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C116H182N36O40S6
Background	omega-Conotoxin RVIA is a 27 amino acid peptidyl toxin, originally isolated from the Conus radiatus (Rayed cone)1 venom and is a synthetic version of the peptide.This peptide acts at presynaptic membranes by binding and blocking voltage-gated Ca2+ channels (CaV2.2)2.
Biological Activity	CaV2.2 channel blocker1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2913.3 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P58914
Concentration	1 - 5 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys1-Cys16, Cys8-Cys19, Cys15-Cys26 X = Hydroxyproline
Origin	Conus radiatus (Rayed cone)

Synonyms	Omega-conotoxin RVIA
Gene Id	CACNA1B
Sequence	CKPXGSXCRVSSYNCCSSCKSYNKKCG-OH
Target	CaV2.2 Ca2+ channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Abbott, J.R. and Litzinger M.J. (1994) Int. J. Devl. Neuroscience 12, 43. Olivera, B.M. et al. (1994) Annu. Rev. Biochem. 63, 823. Abbott, J.R. and Litzinger M.J. (1994) Int. J. Devl. Neuroscience 12, 43.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300194-1	STC-850_0.1 mg	0.1 mg	$188		Add to Cart
BHP21300194-2	STC-850_0.25 mg	0.25 mg	$336		Add to Cart
BHP21300194-3	STC-850_0.5 mg	0.5 mg	$448		Add to Cart

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