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Home / Proteins & Peptide / Proteins

omega-Conotoxin MVIIA

SKU : BHP21300034

A Specific Blocker of CaV2.2 Channel

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Mfr.No.	C-670, C-670_0.1 mg, C-670_0.25 mg, C-670_0.5 mg, C-670_1 mg, C-670_10 mg, C-670_5 mg
Description	A Specific Blocker of CaV2.2 Channel
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C102H172N36O32S7
Background	omega-Conotoxin MVIIA is a synthetic peptidyl toxin originally isolated from Conus magus snail venoM omega-Conotoxin MVIIA specifically blocks CaV2.2 (alpha1B, N-type) channels1. The effect of the toxin is modulated by CaVbeta auxiliary subunit2 and by voltage (i.e. it is more potent for inactivated channels)3.omega-Conotoxin MVIIA inhibits K+-induced 3H-GABA release in hippocampus in vivo4. This effect was with high affinity (50% block, 200 nM). The toxin was used to inhibit synaptic transmission in several peripheral preparations5,6,7. The toxin binds with high affinity to rat neocortical membranes8. It blocked cloned CaV2.2 channels transiently expressed in tsa-2019 and in Xenopus oocytes3.The FDA recently approved Prialt (synthetic omega-Conotoxin MVIIA) to treat severe chronic pain in patients who are intolerant of or refractory to other treatments such as systemic analgesics or other pain medication such as opiates. This is the first ion channel blocker to be marketed for pain.
Biological Activity	omega-Conotoxin MVIIA specifically blocks N-type CaV channels1 and also inhibits K+-induced 3H-GABA release in the hippocampus in vivo2.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2639.2 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P05484
Concentration	100 nM - 2 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
Cas Number	107452-89-1
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys1-Cys16, Cys8-Cys20 and Cys15-Cys25 Cys25 - C-terminal amidation
Origin	Conus magus (Magical cone)

Synonyms	SNX-111, Omega-conotoxin MVIIA, Ziconotide
Gene Id	CACNA1B
Sequence	CKGKGAKCSRLMYDCCTGSCRSGKC-NH2
Target	CaV2.2 Ca2+ channel

Country Of Origin	Israel/IL
Purity	>=99% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Olivera, B.M. et al. (1987) Biochemistry 26, 2086. Luchian, T. (2001) Biochim. Biophys. Acta. 1512, 329. Stocker, J.W. et al. (1997) J. Neurosci 17, 3002. Newcomb, R. et al. (1994) Brain. Res. 638, 95. Vega, T. et al. (1995) Eur. J. Pharmacol. 276, 231. Hirata, H. et al. (1997) Eur. J. Pharmacol. 321, 217. Sanger, G.J. et al. (2000) Eur. J. Pharmacol. 388, 89. Stoehr, S.J. et al. (1993) Neurosci. Lett. 161, 113. Olivera, B.M. et al. (1987) Biochemistry 26, 2086. Newcomb, R. et al. (1994) Brain. Res. 638, 95.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300034-1	C-670_0.1 mg	0.1 mg	$108		Add to Cart
BHP21300034-2	C-670_0.25 mg	0.25 mg	$198		Add to Cart
BHP21300034-3	C-670_0.5 mg	0.5 mg	$306		Add to Cart
BHP21300034-4	C-670_1 mg	1 mg	$490		Add to Cart
BHP21300034-5	C-670_10 mg	10 mg	$2395		Add to Cart
BHP21300034-6	C-670_5 mg	5 mg	$1710		Add to Cart

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