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Home / Proteins & Peptide / Proteins

omega-Conotoxin MoVIA

SKU : BHP21300150

A Potent Blocker of CaV2.2 Channel

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Mfr.No.	STC-150, STC-150_0.1 mg, STC-150_0.5 mg, STC-150_1 mg, STC-150_10 mg, STC-150_5 mg, STC-150_50 mcg
Description	A Potent Blocker of CaV2.2 Channel
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C147H233N45O47S7
Background	omega-Conotoxin MoVIA (MoVIA) is a 29 amino acid peptidyl toxin originally isolated from the venom of the western Pacific vermivorous (worm-hunting) cone snail, Conus moncuri. MoVIA is a specific and potent blocker of mammalian N-type voltage-gated Ca2+ channels (CaV2.2)1.MoVIA has an arginine at position 13 instead of a tyrosine, which has been previously shown to be functionally critical for the potent Cav2.2 inhibitor activity of omega-conotoxins including omega-Conotoxin MVIIA (#C-670) and omega-Conotoxin GVIA (#C-300) from piscivorous (fish-hunting) species1.CaV2.2 are predominantly expressed in nerve terminals and are involved in the regulation of neuronal excitability and nociceptive signaling. These channels are multifunctional and play important roles in the transduction of acute and chronic pain perception. They are able to transduce electrical activity into other cellular functions, regulate calcium homeostasis and process pain information. Since omega-conotoxins selectively inhibit Cav2.2 in nociceptors, they are considered attractive molecules for drug design2.
Biological Activity	A selective Cav2.2 blocker1
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	3607 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	A0A384E129
Concentration	100 nM - 2 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys1-Cys16, Cys8-Cys19, Cys15-Cys26 X = Hydroxyproline
Origin	Conus moncuri (Sea snail)

Synonyms	Omega-conotoxin MoVIA
Gene Id	CACNA1B
Sequence	CKPXGSKCSXSMRDCCTTCISYTKRCRKYYN-OH
Target	Cav2.2

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Silmara, R. S. et al. (2018) Sci. Rep., 8, 13397. Adams, D.J. and Berecki, G. (2013) Biochim. Biophys. Acta. 1828, 1619.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300150-1	STC-150_0.1 mg	0.1 mg	$185		Add to Cart
BHP21300150-2	STC-150_0.5 mg	0.5 mg	$656		Add to Cart
BHP21300150-3	STC-150_1 mg	1 mg	$1051		Add to Cart
BHP21300150-4	STC-150_10 mg	10 mg	$5903		Add to Cart
BHP21300150-5	STC-150_5 mg	5 mg	$3690		Add to Cart
BHP21300150-6	STC-150_50 mcg	50 mcg	$152		Add to Cart

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