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Home / Proteins & Peptide / Proteins

omega-Conotoxin FVIA

SKU : BHP21300191

A Potent Blocker of CaV2.2 Channel

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Mfr.No.	STC-780, STC-780_0.1 mg, STC-780_0.5 mg, STC-780_1 mg, STC-780_5 mg, STC-780_50 mcg
Description	A Potent Blocker of CaV2.2 Channel
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C98H164N36O33S6
Background	omega-Conotoxins are disulfide-rich peptides comprised of 24-31 amino acids, isolated from the venom of marine predatory cone snails. They have a high content of basic amino acid residue and common cysteine scaffold that stabilizes the four-loop framework1,2.omega-Conotoxin FVIA is originally isolated from Conus Fulmen. It is a selective, potent and reversible voltage-gated N-Type Ca2+ (CaV2.2) channel blocker that preferentially blocks nociception in inflammatory pain models, and allodynia and hyperalgesia in neuropathic pain models1,2. Studies have shown that omega-Conotoxin FVIA demonstrates analgesic potency and greater reversibility for the treatment of refractory pain and low side effects1.Voltage-gated N-Type Ca2+ channels are predominantly expressed in nerve terminals and are involved in the regulation of neuronal excitability and nociceptive signals. They are able to transduce electrical activity into other cellular functions and regulate calcium homeostasis2.
Biological Activity	omega-Conotoxin FVIA specifically and reversibly blocks N-type Ca2+ channels1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2567 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P0DW83
Concentration	10 - 50 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys1-Cys16, Cys8-Cys20, and Cys15-Cys25 Cys25 - C-terminal amidation
Origin	Conus fulmen (Thunderbolt cone) (Chelyconus fulmen)

Synonyms	Conotoxin FVIA
Gene Id	CACNA1B
Sequence	CKGTGKSCSRIAYNCCTGSCRSGKC-NH2
Target	CaV2.2 channels

Country Of Origin	Israel/IL
Purity	>=99% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Adams, D.J. et al. (2013) Biochim. Biophys. Acta. 1828, 1619. Adams, D.J. et al. (2013) Biochim. Biophys. Acta. 1828, 1619. Lee, S. et al. (2010) Mol. Pain 6, 97. Lee, S. et al. (2010) Mol. Pain 6, 97. Lee, S. et al. (2010) Mol. Pain 6, 97.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300191-1	STC-780_0.1 mg	0.1 mg	$184		Add to Cart
BHP21300191-2	STC-780_0.5 mg	0.1 mg	$509		Add to Cart
BHP21300191-3	STC-780_1 mg	1 mg	$885		Add to Cart
BHP21300191-4	STC-780_5 mg	5 mg	$1710		Add to Cart
BHP21300191-5	STC-780_50 mcg	50 mcg	$151		Add to Cart

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