JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
orders@biohippo.com

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Proteins & Peptide / Proteins

omega-Conotoxin CVIF

SKU : BHP21300189

A Blocker of N-Type CaV Channels

Contact us to order

Tel

+1 866.986.9598

Email

orders@biohippo.com

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

orders@biohippo.com

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	STC-770, STC-770_0.1 mg, STC-770_0.5 mg, STC-770_1 mg, STC-770_10 mg, STC-770_5 mg, STC-770_50 mcg
Description	A Blocker of N-Type CaV Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C101H170N40O33S6
Background	omega-Conotoxin CVIF is a peptide toxin originally isolated from Conus catus venoM It selectively blocks voltage-gated N-type Ca2+ channel and is being tested as a potential drug for the treatment of chronic and neuropathic pain. CVIF has a higher affinity for Ca2+ channels in their inactivated state.Neuronal (N)-type voltage-gated Ca2+channels (VGCCs) are involved in regulating neuronal excitability and nociceptive signals and play an important role in the transduction of acute and chronic pain perception. The VGCC channel residues that directly interact with omega-conotoxins, act at or near the outer vestibule of N-type (CaV2.2) and P/Q-type (CaV2.1) VGCCs1.CVIF can prevent the conduction of nociceptive signals from the peripheral to the central nervous system by inhibiting neurotransmitter release from primary afferent nerve terminals in the dorsal horn of the spinal cord1,2.CVIF has the ability to potently and selectively inhibit depolarization-activated Ba2+ currents through recombinant N-type Ca2+ channels in snails' oocytes1.
Biological Activity	omega-Conotoxin CVIF is an N-type Ca2+ channel blocker1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2665 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P0DQD4
Concentration	50 - 100 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys1-Cys16, Cys8-Cys20 and Cys15-Cys27 Cys27 - C-terminal amidation
Origin	Conus catus (Cat cone)

Synonyms	Omega conotoxin-CVIF
Gene Id	CACNA1B
Sequence	CKGKGASCRRTSYDCCTGSCRLGRC-NH2
Target	CaV2.2 channels

Country Of Origin	Israel/IL
Purity	>=99% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Berecki, G. et al. (2010) Mol. Pharmacol. 77, 139. Sadeghi, M. et al. (2013) Mol. Pain 9, 51. Berecki, G. et al. (2010) Mol. Pharmacol. 77, 139.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300189-1	STC-770_0.1 mg	0.1 mg	$202		Add to Cart
BHP21300189-2	STC-770_0.5 mg	0.5 mg	$561		Add to Cart
BHP21300189-3	STC-770_1 mg	1 mg	$917		Add to Cart
BHP21300189-4	STC-770_10 mg	10 mg	$4620		Add to Cart
BHP21300189-5	STC-770_5 mg	5 mg	$3299		Add to Cart
BHP21300189-6	STC-770_50 mcg	50 mcg	$170		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.