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Home / Proteins & Peptide / Proteins

omega-Conotoxin CVIB

SKU : BHP21300165

A Blocker of N-, P/Q-Type Ca2+ Channels

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Mfr.No.	STC-410, STC-410_0.1 mg, STC-410_0.5 mg, STC-410_1 mg, STC-410_50 mcg
Description	A Blocker of N-, P/Q-Type Ca2+ Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C102H173N41O32S7
Background	omega-Conotoxin CVIB is a peptide toxin originally isolated from the cat cone (Conus Catus). It is a blocker of voltage-gated N-,P- and Q-type CaV channels. CVIB has an effective concentration of 1-10 nM with an IC50 of 7.7 nM for N-type channels and 11 nM for P- and Q-type channels. Compared to other omega-conotoxins, CVIB is a fairly poor inhibitor of N-type channels and only a moderate inhibitor of P- and Q-type channels. Cloning and sequencing of mRNA transcripts from the venom ducts of the sea-snail failed to isolate CVIB's mRNA transcript thus suggesting that this omega-conotoxin is not found abundantly in the Conus Catus species and may be found in other species of the cone snail family1.
Biological Activity	omega-Conotoxin CVIB is a N-, P- and Q-type calcium channel blocker1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	2710 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P58918
Concentration	1 - 10 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys1-Cys16, Cys8-Cys20 and Cys15-Cys25 Cys25 - C-terminal amidation
Origin	Conus catus (Cat cone)

Synonyms	Omega-conotoxin CVIB
Gene Id	CACNA1A,CACNA1B
Sequence	CKGKGASCRKTMYDCCRGSCRSGRC-NH2
Target	N-, P/Q-type Ca2+ channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Lewis, R.J. et al. (2000) J. Biol. Chem. 275, 35335. Lewis, R.J. et al. (2000) J. Biol. Chem. 275, 35335.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300165-1	STC-410_0.1 mg	0.1 mg	$287		Add to Cart
BHP21300165-2	STC-410_0.5 mg	0.5 mg	$1139		Add to Cart
BHP21300165-3	STC-410_1 mg	1 mg	$1597		Add to Cart
BHP21300165-4	STC-410_50 mcg	50 mcg	$170		Add to Cart

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