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Home / Proteins & Peptide / Proteins

omega-Agatoxin IVA

SKU : BHP21300133

A Blocker of P/Q-Type CaV Channels

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Mfr.No.	STA-500, STA-500_0.1 mg, STA-500_0.25 mg, STA-500_0.5 mg, STA-500_1 mg, STA-500_10 mg, STA-500_2.5 mg, STA-500_5 mg
Description	A Blocker of P/Q-Type CaV Channels
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C217H360N68O60S10
Background	Native omega-Agatoxin IVA (omega-Aga-IVA) was originally isolated from Agelenopsis aperta spider venom, and was shown to be a selective blocker of CaV2.1 (P/Q type) channels1. However, the sensitivity depends on the auxiliary b subunit isoform2 and on the splice variant3. Therefore, the effective concentration varies between systems. In accordance, the toxin blocks presynaptic Ca2+ currents and synaptic transmission in a variety of synapses4,5.omega-Agatoxin IVA is widely used in electrophysiological measurements of cloned and native channels6,7. It is used to assess the role of CaV2.1 channels in synaptic transmission4. In addition, it was used to map the spatial distribution of CaV2.1 channels in mouse cerebellar and hippocampal brain slices8.
Biological Activity	omega-Agatoxin IVA is an antagonist of voltage-sensitive P-type Ca2+ channels1. It blocks neuromuscular transmission presynaptically in a variety of synapses2,3.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	5202 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	P30288
Concentration	20 nM - 1 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Cited Application: Electrophysiology Is Toxin: Yes
Cas Number	145017-83-0
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys4-Cys20, Cys12-Cys25, Cys19-Cys36 and Cys27-Cys34
Origin	Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)

Synonyms	Omega-agatoxin-Aa4a, omega-AGTX-Aa4a, omega-Aga-IVA, omega-agatoxin-4A
Gene Id	CACNA1A
Sequence	KKKCIAKDYGRCKWGGTPCCRGRGCICSIMGTNCECKPRLIMEGLGLA-OH
Target	P-type Ca2+ channels

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Mintz, I.M. et al. (1992) Nature 355, 827. Moreno, H. et al. (1997) Proc. Natl. Acad. Sci. 94, 14042. Bourinet, E. et al. (1999) Nat. Neurosci. 2, 407. Meir, A. et al. (1999) Physiol. Rev. 79, 1019. Stephens, G.J. et al. (2001) Eur. J. Neurosci. 13, 1902. Berrow, N.S. et al. (1997) Eur. J. Neurosci. 9, 739. Pearson, H.A. et al. (1995) J. Physiol. 482, 493. Nakanishi, S. et al. (1995) J. Neurosci. Res. 41, 532. Mintz, I. et al. (1992) Nature 355, 827. Meir, A. et al. (1999) Physiol. Rev. 79, 1019. Stephens, G.J. et al. (2001) Eur. J. Neurosci. 13, 1902.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300133-1	STA-500_0.1 mg	0.1 mg	$185		Add to Cart
BHP21300133-2	STA-500_0.25 mg	0.25 mg	$419		Add to Cart
BHP21300133-3	STA-500_0.5 mg	0.5 mg	$659		Add to Cart
BHP21300133-4	STA-500_1 mg	1 mg	$1062		Add to Cart
BHP21300133-5	STA-500_10 mg	10 mg	$4726		Add to Cart
BHP21300133-6	STA-500_2.5 mg	2.5 mg	$2109		Add to Cart
BHP21300133-7	STA-500_5 mg	5 mg	$3375		Add to Cart

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