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Home / Proteins & Peptide / Proteins

MMK1

SKU : BHP21300062

A Potent and Selective Agonist of FPR2 G-Protein Coupled Receptors

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Mfr.No.	GPM-120, GPM-120_1 mg, GPM-120_25 mg, GPM-120_5 mg
Description	A Potent and Selective Agonist of FPR2 G-Protein Coupled Receptors
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C75H123N19O18S1
Background	Chemotactic factors from both Gram-positive and Gram-negative bacteria are short peptides with N-formyl methionine at the N-terminus (extensively reviewed in reference 1). These peptides are released from bacteria during infection and activate formyl peptide receptors (FPR), members of the G-protein coupled receptor (GPCR) superfamily. In humans, the FPR family consists mainly of three receptors, FPR1, FPR2/ALX (formerly FPRL1), and FPR3 (formerly FPRL2) which all couple to the Gi subtype of G-proteins and ultimately lead to the activation of phospholipase C and intracellular Ca2+ increase1,2.MMK1 is a selective and potent agonist of the Formyl peptide receptor FPR23, which was originally derived from a random peptide library and was identified by a novel autocrine selection method in yeast engineered to express human FPR24.FPR2 is expressed in the promyelocytic leukemia cell line HL-60 as well as in the chronic myelogenous leukemia cell line K5625. In human neutrophils, 1 uM MMK1 induces Ca2+ influx which is blocked by the specific FPR2 antagonist WRW46.Resveratrol, a constituent of grape seeds, induces Ca2+ influx in human monocytes which is blocked by 10 uM MMK1, demonstrating that the inhibition of chemoattractant receptors contribute to the anti-inflammatory properties of resveratrol7.
Biological Activity	MMK1 is a selective and potent agonist of the formyl peptide receptor (FPR2)1.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	1611 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Concentration	1 nM - 10 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: No
Cas Number	271246-66-3
UNSPSC Code	12352202
Lead Time	1-2 Business Days

Synonyms	FPR2 agonist
Gene Id	FPR2
Sequence	LESIFRSLLFRVM-OH
Target	FPR2 receptor

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Calcium imaging assay

Reference	Le, Y. et al. (2002) Trends Immunol. 23, 541. Hu, J.Y. et al. (2001) J. Leukoc. Biol. 70, 155. Klein, C. et al. (1998) Nat. Biotechnol. 16, 1334. See Applications for Anti-Human FPR2/ALX (extracellular) Antibody. Bae, Y.S. et al. (2004) J. Immunol. 173, 607. Tao, H.Y. et al. (2004) Cell. Mol. Immunol. 1, 50. Ye, R.D. et al. (2009) Pharmacol. Rev. 61, 119.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300062-1	GPM-120_1 mg	1 mg	$168		Add to Cart
BHP21300062-2	GPM-120_25 mg	25 mg	$1268		Add to Cart
BHP21300062-3	GPM-120_5 mg	5 mg	$502		Add to Cart

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